Evidence map›Paper›PMID 25834324›Full record

ArticleWorld journal of gastroenterology2015

Appropriate empirical antibiotic use and 30-d mortality in cirrhotic patients with bacteremia.

Hyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Dong Hyun Sinn

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Microbial Infections as a Trigger for Acute-on-Chronic Liver Failure: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hyun ParkHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Ki Jun JangHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Won JangHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Sang Hoon ParkHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Ji Young ParkHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Tae Joo JeonHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Tae Hoon OhHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Won Chang ShinHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Won-Choong ChoiHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Dong Hyun SinnHyun Park, Ki Jun Jang, Won Jang, Sang Hoon Park, Ji Young Park, Tae Joo Jeon, Tae Hoon Oh, Won Chang Shin, Won-Choong Choi, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul 135-710, South Korea.
Wonkwang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo analyze whether prompt and appropriate empirical antibiotic (AEA) use is associated with mortality in cirrhotic patients with bacteremia.

methodsA total of 102 episodes of bacteremia in 72 patients with cirrhosis were analyzed. AEA was defined as a using or starting an antibiotic appropriate to the isolated pathogen at the time of bacteremia. The primary endpoint was 30-d mortality.

resultsThe mortality rate at 30 d was 30.4% (31/102 episodes). Use of AEA was associated with better survival at 30 d (76.5% vs 46.9%, P = 0.05), and inappropriate empirical antibiotic (IEA) use was an independent factor associated with increased mortality (OR = 3.24; 95%CI: 1.50-7.00; P = 0.003, adjusted for age, sex, Child-Pugh Class, gastrointestinal bleeding, presence of septic shock). IEA use was more frequent when the isolated pathogen was a multiresistant pathogen, and when infection was healthcare-related or hospital-acquired.

conclusionAEA use was associated with increased survival of cirrhotic patients who developed bacteremia. Strategies for AEA use, tailored according to the local epidemiological patterns, are needed to improve survival of cirrhotic patients with bacteremia.

Indexed as

Inappropriate PrescribingAgedAnti-Bacterial AgentsBacteremiaDrug Resistance, Multiple, BacterialFemaleHumansKaplan-Meier EstimateLiver CirrhosisMaleMicrobial Sensitivity TestsMiddle AgedMultivariate AnalysisOdds RatioPredictive Value of TestsProportional Hazards ModelsAnti-Bacterial AgentsAppropriate antibioticsBacteremiaLiver cirrhosisMultiresistant pathogenSurvival

Identifiers

PMID25834324
PMCPMC4375581
OpenAlexW2086023528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.