Evidence map›Paper›PMID 25834313›Full record

ReviewWorld journal of gastroenterology2015

Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: an update.

Sheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Yan Ouyang, Kai Qing

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 1 synthesis or guideline pooled it, 221 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  8. Review
  9. Article
  10. The impact of lipid metabolism on ferroptosis in myocardial ischemia-reperfusion injury.Apoptosis : an international journal on programmed cell death · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. miR-375 protects against acetaminophen-induced acute liver failure by orchestrating pharmacogene expression.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sheng YanSheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Department of Gastroenterology, Affiliated Nanhua Hospital of University of South China, Hengyang 421001, Hunan Province, China.
Xue-Feng YangSheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Department of Gastroenterology, Affiliated Nanhua Hospital of University of South China, Hengyang 421001, Hunan Province, China.
Hao-Lei LiuSheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Department of Gastroenterology, Affiliated Nanhua Hospital of University of South China, Hengyang 421001, Hunan Province, China.
Nian FuSheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Department of Gastroenterology, Affiliated Nanhua Hospital of University of South China, Hengyang 421001, Hunan Province, China.
Yan OuyangSheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Department of Gastroenterology, Affiliated Nanhua Hospital of University of South China, Hengyang 421001, Hunan Province, China.
Kai QingSheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Department of Gastroenterology, Affiliated Nanhua Hospital of University of South China, Hengyang 421001, Hunan Province, China.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-chain acyl-CoA synthetase (ACSL) family members include five different ACSL isoforms, each encoded by a separate gene and have multiple spliced variants. ACSLs on endoplasmic reticulum and mitochondrial outer membrance catalyze fatty acids with chain lengths from 12 to 20 carbon atoms to form acyl-CoAs, which are lipid metabolic intermediates and involved in fatty acid metabolism, membrane modifications and various physiological processes. Gain- or loss-of-function studies have shown that the expression of individual ACSL isoforms can alter the distribution and amount of intracellular fatty acids. Changes in the types and amounts of fatty acids, in turn, can alter the expression of intracellular ACSLs. ACSL family members affect not only the proliferation of normal cells, but the proliferation of malignant tumor cells. They also regulate cell apoptosis through different signaling pathways and molecular mechanisms. ACSL members have individual functions in fatty acid metabolism in different types of cells depending on substrate preferences, subcellular location and tissue specificity, thus contributing to liver diseases and metabolic diseases, such as fatty liver disease, obesity, atherosclerosis and diabetes. They are also linked to neurological disorders and other diseases. However, the mechanisms are unclear. This review addresses new findings in the classification and properties of ACSLs and the fatty acid metabolism-associated effects of ACSLs in diseases.

Indexed as

AnimalsApoptosisCell ProliferationCoenzyme A LigasesFatty AcidsHumansIsoenzymesLiverLiver DiseasesLong-Chain-Fatty-Acid-CoA LigaseMetabolic DiseasesNervous System DiseasesSignal TransductionCoenzyme A LigasesFatty AcidsIsoenzymesLong-Chain-Fatty-Acid-CoA LigaseApoptosisFatty acidLiver diseasesLong-chain acyl-CoA synthetaseMetabolic diseasesPathwaysProliferation

Identifiers

PMID25834313
PMCPMC4375570
OpenAlexW2032611127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.