Evidence map›Paper›PMID 25834081›Full record

ArticleThe Journal of bone and joint surgery. American volume2015

Architectural and biochemical adaptations in skeletal muscle and bone following rotator cuff injury in a rat model.

Eugene J Sato, Megan L Killian, Anthony J Choi, Evie Lin, Alexander D Choo, Ana E Rodriguez-Soto, Chanteak T Lim, Stavros Thomopoulos, Leesa M Galatz, Samuel R Ward

Abstract read
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In one paragraph

Article in The Journal of bone and joint surgery. American volume, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Context-dependent roles of 11β-HSD1 in bone and skeletal muscle diseases.American journal of translational research · 2026
    Review
  2. Article
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  5. Effects of spaceflight on the muscles of the murine shoulder.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017
    Article
  6. Article
  7. Article
  8. Article
  9. A method to test contractility of the supraspinatus muscle in mouse, rat, and rabbit.Journal of applied physiology (Bethesda, Md. : 1985) · 2016
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eugene J SatoDepartments of Bioengineering (E.J.S., A.E.R.-S., and S.R.W.), Radiology (S.R.W.), and Orthopaedic Surgery (A.J.C., E.L., A.D.C., and S.R.W.), University of California San Diego, 9500 Gilman Drive (0610), La Jolla, CA 92093. E-mail address for S.R. Ward: srward@ucsd.edu.
Megan L KillianDepartment of Orthopaedic Surgery, Washington University, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail address for L.M. Galatz: galatzl@wudosis.wustl.edu.
Anthony J ChoiDepartments of Bioengineering (E.J.S., A.E.R.-S., and S.R.W.), Radiology (S.R.W.), and Orthopaedic Surgery (A.J.C., E.L., A.D.C., and S.R.W.), University of California San Diego, 9500 Gilman Drive (0610), La Jolla, CA 92093. E-mail address for S.R. Ward: srward@ucsd.edu.
Evie LinDepartments of Bioengineering (E.J.S., A.E.R.-S., and S.R.W.), Radiology (S.R.W.), and Orthopaedic Surgery (A.J.C., E.L., A.D.C., and S.R.W.), University of California San Diego, 9500 Gilman Drive (0610), La Jolla, CA 92093. E-mail address for S.R. Ward: srward@ucsd.edu.
Alexander D ChooDepartments of Bioengineering (E.J.S., A.E.R.-S., and S.R.W.), Radiology (S.R.W.), and Orthopaedic Surgery (A.J.C., E.L., A.D.C., and S.R.W.), University of California San Diego, 9500 Gilman Drive (0610), La Jolla, CA 92093. E-mail address for S.R. Ward: srward@ucsd.edu.
Ana E Rodriguez-SotoDepartments of Bioengineering (E.J.S., A.E.R.-S., and S.R.W.), Radiology (S.R.W.), and Orthopaedic Surgery (A.J.C., E.L., A.D.C., and S.R.W.), University of California San Diego, 9500 Gilman Drive (0610), La Jolla, CA 92093. E-mail address for S.R. Ward: srward@ucsd.edu.
Chanteak T LimDepartment of Orthopaedic Surgery, Washington University, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail address for L.M. Galatz: galatzl@wudosis.wustl.edu.
Stavros ThomopoulosDepartment of Orthopaedic Surgery, Washington University, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail address for L.M. Galatz: galatzl@wudosis.wustl.edu.
Leesa M GalatzDepartment of Orthopaedic Surgery, Washington University, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail address for L.M. Galatz: galatzl@wudosis.wustl.edu.
Samuel R WardDepartments of Bioengineering (E.J.S., A.E.R.-S., and S.R.W.), Radiology (S.R.W.), and Orthopaedic Surgery (A.J.C., E.L., A.D.C., and S.R.W.), University of California San Diego, 9500 Gilman Drive (0610), La Jolla, CA 92093. E-mail address for S.R. Ward: srward@ucsd.edu.

Funding

National Center for Muscle Rehabilitation ResearchR24HD050837 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIEBER, RICHARD L., WARD, SAMUEL RICHARD · 2005 to 2014
$7.2M
The Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2009 to 2018
$5.7M
Rotator Cuff Degeneration and RepairR01AR057836 · NIAMS · WASHINGTON UNIVERSITY · PI GALATZ, LEESA M, THOMOPOULOS, STAVROS · 2010 to 2020
$3.1M
Predoctoral Training in Translational Musculoskeletal ResearchT32AR060712 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIEBER, RICHARD L., SAH, ROBERT L · 2012 to 2016
$741k
NIAMS NIH HHS P30 AR057235NIAMS NIH HHS R01 AR0578NIAMS NIH HHS R01 AR057836NIAMS NIH HHS T32 AR060712NICHD NIH HHS R24 HD050837
6 · The paper itself

Abstract

backgroundInjury to the rotator cuff can cause irreversible changes to the structure and function of the associated muscles and bones. The temporal progression and pathomechanisms associated with these adaptations are unclear. The purpose of this study was to investigate the time course of structural muscle and osseous changes in a rat model of a massive rotator cuff tear.

methodsSupraspinatus and infraspinatus muscle architecture and biochemistry and humeral and scapular morphological parameters were measured three days, eight weeks, and sixteen weeks after dual tenotomy with and without chemical paralysis via botulinum toxin A (BTX).

resultsMuscle mass and physiological cross-sectional area increased over time in the age-matched control animals, decreased over time in the tenotomy+BTX group, and remained nearly the same in the tenotomy-alone group. Tenotomy+BTX led to increased extracellular collagen in the muscle. Changes in scapular bone morphology were observed in both experimental groups, consistent with reductions in load transmission across the joint.

conclusionsThese data suggest that tenotomy alone interferes with normal age-related muscle growth. The addition of chemical paralysis yielded profound structural changes to the muscle and bone, potentially leading to impaired muscle function, increased muscle stiffness, and decreased bone strength. CLINICAL RELEVANCE: Structural musculoskeletal changes occur after tendon injury, and these changes are severely exacerbated with the addition of neuromuscular compromise.

Indexed as

Rotator Cuff InjuriesAdaptation, PhysiologicalAnimalsBone and BonesDisease Models, AnimalMaleMuscle, SkeletalRats, Sprague-DawleyTendon Injuries

Identifiers

PMID25834081
PMCPMC4372988

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.