ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Neuronal-derived nitric oxide and somatodendritically released vasopressin regulate neurovascular coupling in the rat hypothalamic supraoptic nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Heart failure-induced reprogramming of salt-evoked neurovascular coupling in the rat hypothalamus.The Journal of physiology · 2026Article
- Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Molecular Interaction Between Vasopressin and Insulin in Regulation of Metabolism: Impact on Cardiovascular and Metabolic Diseases.International journal of molecular sciences · 2024Review
- Article
- Quantitative relationship between cerebrovascular network and neuronal cell types in mice.Cell reports · 2022Article
- Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model.Fluids and barriers of the CNS · 2022Article
- Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge.Cell reports · 2021Article
- Guidelines for the measurement of vascular function and structure in isolated arteries and veins.American journal of physiology. Heart and circulatory physiology · 2021Review
- Cerebral Microcirculation, Perivascular Unit, and Glymphatic System: Role of Aquaporin-4 as the Gatekeeper for Water Homeostasis.Frontiers in neurology · 2021Review
- Nitric oxide signalling in the brain and its control of bodily functions.British journal of pharmacology · 2020Review
- Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.Journal of neuroendocrinology · 2020Review
- Vascular and neural basis of the BOLD signal.Current opinion in neurobiology · 2019Review
- Small Vessels Are a Big Problem in Neurodegeneration and Neuroprotection.Frontiers in neurology · 2019Review
- Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain.Scientific reports · 2018Article
- The role of astrocytic calcium and TRPV4 channels in neurovascular coupling.Journal of computational neuroscience · 2018Article
- Astroglial Modulation of Hydromineral Balance and Cerebral Edema.Frontiers in molecular neuroscience · 2018Review
- Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation.Physiological reports · 2017Article
- Effects of Voluntary Locomotion and Calcitonin Gene-Related Peptide on the Dynamics of Single Dural Vessels in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The classical model of neurovascular coupling (NVC) implies that activity-dependent axonal glutamate release at synapses evokes the production and release of vasoactive signals from both neurons and astrocytes, which dilate arterioles, increasing in turn cerebral blood flow (CBF) to areas with increased metabolic needs. However, whether this model is applicable to brain areas that also use less conventional neurotransmitters, such as neuropeptides, is currently unknown. To this end, we studied NVC in the rat hypothalamic magnocellular neurosecretory system (MNS) of the supraoptic nucleus (SON), in which dendritic release of neuropeptides, including vasopressin (VP), constitutes a key signaling modality influencing neuronal and network activity. Using a multidisciplinary approach, we investigated vasopressin-mediated vascular responses in SON arterioles of hypothalamic brain slices of Wistar or VP-eGFP Wistar rats. Bath-applied VP significantly constricted SON arterioles (Δ-41 ± 7%) via activation of the V1a receptor subtype. Vasoconstrictions were also observed in response to single VP neuronal stimulation (Δ-18 ± 2%), an effect prevented by V1a receptor blockade (V2255), supporting local dendritic VP release as the key signal mediating activity-dependent vasoconstrictions. Conversely, osmotically driven magnocellular neurosecretory neuronal population activity leads to a predominant nitric oxide-mediated vasodilation (Δ19 ± 2%). Activity-dependent vasodilations were followed by a VP-mediated vasoconstriction, which acted to limit the magnitude of the vasodilation and served to reset vascular tone following activity-dependent vasodilation. Together, our results unveiled a unique and complex form of NVC in the MNS, supporting a competitive balance between nitric oxide and activity-dependent dendritic released VP, in the generation of proper NVC responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.