ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 41 citations in OpenAlex.
- Migration of dI5 Reelin-Lmx1b-Zfhx3 and Disabled-1-Lmx1b-Zfhx3 neurons contribute to the superficial dorsal horn and lamina V.bioRxiv : the preprint server for biology · 2026Article
- MSK1 Downstream Signaling Contributes to Inflammatory Pain in the Superficial Spinal Dorsal Horn.International journal of molecular sciences · 2025Article
- Human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry recapitulates opioid induced effects.bioRxiv : the preprint server for biology · 2025Article
- Molecular Ontology of the Nucleus of Solitary Tract.The Journal of comparative neurology · 2024Article
- Direct comparison of Hoxb8-driven reporter distribution in the brains of four transgenic mouse lines: towards a spinofugal projection atlas.Frontiers in neuroanatomy · 2024Article
- A perspective: neuraxial therapeutics in pain management: now and future.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp.JCI insight · 2023Article
- Optogenetic and Chemogenic Control of Pain Signaling: Molecular Markers.International journal of molecular sciences · 2023Review
- Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model.Molecular autism · 2023Article
- Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A novel spinal neuron connection for heat sensation.Neuron · 2022Article
- Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans.Cell reports · 2020Article
- Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice.The European journal of neuroscience · 2020Article
- Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.Cell reports · 2019Article
- Neuronal diversity in the somatosensory system: bridging the gap between cell type and function.Current opinion in neurobiology · 2019Review
- Aldosterone-sensitive HSD2 neurons in mice.Brain structure & function · 2019Article
- New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord.Current topics in developmental biology · 2019Review
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Spinal cord neurons respond to peripheral noxious stimuli and relay this information to higher brain centers, but the molecules controlling the assembly of such pathways are poorly known. In this study, we use the intersection of Lmx1b and Hoxb8::Cre expression in the spinal cord to genetically define nociceptive circuits. Specifically, we show that Lmx1b, previously shown to be expressed in glutamatergic dorsal horn neurons and critical for dorsal horn development, is expressed in nociceptive dorsal horn neurons and that its deletion results in the specific loss of excitatory dorsal horn neurons by apoptosis, without any effect on inhibitory neuron numbers. To assess the behavioral consequences of Lmx1b deletion in the spinal cord, we used the brain-sparing driver Hoxb8::Cre. We show that such a deletion of Lmxb1 leads to a robust reduction in sensitivity to mechanical and thermal noxious stimulation. Furthermore, such conditional mutant mice show a loss of a subpopulation of glutamatergic dorsal horn neurons, abnormal sensory afferent innervations, and reduced spinofugal innervation of the parabrachial nucleus and the periaqueductal gray, important nociceptive structures. Together, our results demonstrate an important role for the intersection of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.