ArticleDatabase : the journal of biological databases and curation2015
CHOPIN: a web resource for the structural and functional proteome of Mycobacterium tuberculosis.
Article in Database : the journal of biological databases and curation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Utilizing graph machine learning within drug discovery and development.Briefings in bioinformatics · 2021Article
- ProtCHOIR: a tool for proteome-scale generation of homo-oligomers.Briefings in bioinformatics · 2021Article
- Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape ofFrontiers in molecular biosciences · 2021Review
- A platform for target prediction of phenotypic screening hit molecules.Journal of molecular graphics & modelling · 2020Article
- Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance.Frontiers in genetics · 2020Review
- Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery.Emerging microbes & infections · 2019Review
- Article
- Mabellini: a genome-wide database for understanding the structural proteome and evaluating prospective antimicrobial targets of the emerging pathogen Mycobacterium abscessus.Database : the journal of biological databases and curation · 2019Article
- Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis.Scientific reports · 2018Article
- Article
- An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences.Acta crystallographica. Section D, Structural biology · 2017Review
- Decoding the similarities and differences among mycobacterial species.PLoS neglected tropical diseases · 2017Article
- SDM: a server for predicting effects of mutations on protein stability.Nucleic acids research · 2017Article
- XSuLT: a web server for structural annotation and representation of sequence-structure alignments.Nucleic acids research · 2017Article
- TIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial species.Database : the journal of biological databases and curation · 2017Article
- SInCRe-structural interactome computational resource for Mycobacterium tuberculosis.Database : the journal of biological databases and curation · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis kills more than a million people annually and presents increasingly high levels of resistance against current first line drugs. Structural information about Mycobacterium tuberculosis (Mtb) proteins is a valuable asset for the development of novel drugs and for understanding the biology of the bacterium; however, only about 10% of the ∼4000 proteins have had their structures determined experimentally. The CHOPIN database assigns structural domains and generates homology models for 2911 sequences, corresponding to ∼73% of the proteome. A sophisticated pipeline allows multiple models to be created using conformational states characteristic of different oligomeric states and ligand binding, such that the models reflect various functional states of the proteins. Additionally, CHOPIN includes structural analyses of mutations potentially associated with drug resistance. Results are made available at the web interface, which also serves as an automatically updated repository of all published Mtb experimental structures. Its RESTful interface allows direct and flexible access to structures and metadata via intuitive URLs, enabling easy programmatic use of the models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.