ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
The role of spinal GABAergic circuits in the control of phrenic nerve motor output.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Targeting drug or gene delivery to the phrenic motoneuron pool.Journal of neurophysiology · 2023Review
- Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats.Journal of neurophysiology · 2021Article
- Pharmacological disinhibition enhances paced breathing following complete spinal cord injury in rats.Respiratory physiology & neurobiology · 2020Article
- Spinal genesis of Mayer waves.Neural regeneration research · 2020Review
- Respiratory resetting elicited by single pulse spinal stimulation.Respiratory physiology & neurobiology · 2020Article
- Modulation of Respiratory System by Limb Muscle Afferents in Intact and Injured Spinal Cord.Frontiers in neuroscience · 2019Review
- Role of Propriospinal Neurons in Control of Respiratory Muscles and Recovery of Breathing Following Injury.Frontiers in systems neuroscience · 2019Review
- Microsurgical technique for concurrent cervical corpectomy and ventral phrenic nerve access in the rat.MethodsX · 2019Article
- The Neuroplastic and Therapeutic Potential of Spinal Interneurons in the Injured Spinal Cord.Trends in neurosciences · 2018Review
- Intraspinal microstimulation for respiratory muscle activation.Experimental neurology · 2018Article
- Microsurgical technique for tracheostomy in the rat.MethodsX · 2018Article
- Anatomical Recruitment of Spinal V2a Interneurons into Phrenic Motor Circuitry after High Cervical Spinal Cord Injury.Journal of neurotrauma · 2017Article
- High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury.Journal of neurophysiology · 2017Article
- The crossed phrenic phenomenon.Neural regeneration research · 2017Review
- Coupling multielectrode array recordings with silver labeling of recording sites to study cervical spinal network connectivity.Journal of neurophysiology · 2017Article
- Article
- Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury.Experimental neurology · 2017Review
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Authors and funding
3 authors.
Funding
Abstract
While supraspinal mechanisms underlying respiratory pattern formation are well characterized, the contribution of spinal circuitry to the same remains poorly understood. In this study, we tested the hypothesis that intraspinal GABAergic circuits are involved in shaping phrenic motor output. To this end, we performed bilateral phrenic nerve recordings in anesthetized adult rats and observed neurogram changes in response to knocking down expression of both isoforms (65 and 67 kDa) of glutamate decarboxylase (GAD65/67) using microinjections of anti-GAD65/67 short-interference RNA (siRNA) in the phrenic nucleus. The number of GAD65/67-positive cells was drastically reduced on the side of siRNA microinjections, especially in the lateral aspects of Rexed's laminae VII and IX in the ventral horn of cervical segment C4, but not contralateral to microinjections. We hypothesize that intraspinal GABAergic control of phrenic output is primarily phasic, but also plays an important role in tonic regulation of phrenic discharge. Also, we identified respiration-modulated GABAergic interneurons (both inspiratory and expiratory) located slightly dorsal to the phrenic nucleus. Our data provide the first direct evidence for the existence of intraspinal GABAergic circuits contributing to the formation of phrenic output. The physiological role of local intraspinal inhibition, independent of descending direct bulbospinal control, is discussed.
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