Evidence map›Paper›PMID 25833891›Full record

ReviewThe Journal of nutrition2015

Nutrition and metabolic correlates of obesity and inflammation: clinical considerations.

Amy R Johnson, Liza Makowski

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Murine Models of Obesity-Related Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2025
    Review
  3. Review
  4. Article
  5. pNaKtide Inhibits Na/K-ATPase Signaling and Attenuates Obesity.Journal of clinical and medical sciences · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Effect of Sheng-Jiang Powder on Obesity-Induced Multiple Organ Injuries in Rats.Evidence-based complementary and alternative medicine : eCAM · 2017
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Amy R JohnsonDepartment of Nutrition, Gillings School of Global Public Health, and.
Liza MakowskiDepartment of Nutrition, Gillings School of Global Public Health, and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC liza.makowski@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHARLES M PEROU · 1992 to 2026
$59.3M
Pregnancy, Obesogenic Environments, and Basal-like Breast CancerU01ES019472 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TROESTER, MELISSA A. · 2010 to 2014
$2.3M
Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & ObesityR00AA017376 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAKOWSKI-HAYES, LIZA · 2010 to 2012
$728k
(PQA2) Reversing Carcinogenic Effect of Obesity on Basal-like Breast CancerR21CA180134 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAKOWSKI-HAYES, LIZA · 2013 to 2014
$347k
Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & ObesityK99AA017376 · NIAAA · DUKE UNIVERSITY · PI MAKOWSKI-HAYES, LIZA · 2007 to 2008
$161k
NCI NIH HHS P50 CA058223NCI NIH HHS R21 CA180134NCI NIH HHS R21CA180134NIAAA NIH HHS AA017376NIEHS NIH HHS ES019472PHS HHS F32H117616
6 · The paper itself

Abstract

Since 1980, the global prevalence of obesity has doubled; in the United States, it has almost tripled. Billions of people are overweight and obese; the WHO reports that >65% of the world's population die of diseases related to overweight rather than underweight. Obesity is a complex disease that can be studied from "metropolis to metabolite"—that is, beginning at the policy and the population level through epidemiology and intervention studies; to bench work including preclinical models, tissue, and cell culture studies; to biochemical assays; and to metabolomics. Metabolomics is the next research frontier because it provides a real-time snapshot of biochemical building blocks and products of cellular processes. This report comments on practical considerations when conducting metabolomics research. The pros and cons and important study design concerns are addressed to aid in increasing metabolomics research in the United States. The link between metabolism and inflammation is an understudied phenomenon that has great potential to transform our understanding of immunometabolism in obesity, diabetes, cancer, and other diseases; metabolomics promises to be an important tool in understanding the complex relations between factors contributing to such diseases.

Indexed as

Biomedical ResearchGlobal HealthImmunityMetabolomicsNutritional SciencesAnimalsCongresses as TopicDietHumansMolecular BiologyObesityOverweightWorkforcediabeteshigh-fat dietmacrophagemetabolomicsobesity

Identifiers

PMID25833891
PMCPMC4410497
OpenAlexW1969434564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.