ArticleJournal of neurophysiology2015
Awake vs. anesthetized: layer-specific sensory processing in visual cortex and functional connectivity between cortical areas.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Ferret as a model system for studying the anatomy and function of the prefrontal cortex: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Nonlinear Asymmetric Blood Oxygenation Level Dependent Responses in Somatosensory Cortex.Human brain mapping · 2026Article
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- Parameter-dependent cell-type specific effects of transcranial focused ultrasound stimulation in an awake head-fixed rodent model.Journal of neural engineering · 2025Article
- Neuroimaging Model of Visceral Manipulation in an Awake Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mesoscopic mapping of hemodynamic responses and neuronal activity during pharmacologically induced interictal spikes in awake and anesthetized mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Article
- Anesthetized animal experiments for neuroscience research.Frontiers in neural circuits · 2024Review
- Article
- Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex.Current biology : CB · 2023Article
- Performance Baseline of Phase Transfer Entropy Methods for Detecting Animal Brain Area Interactions.Entropy (Basel, Switzerland) · 2023Article
- Noise improves the association between effects of local stimulation and structural degree of brain networks.PLoS computational biology · 2023Article
- State-dependent effects of neural stimulation on brain function and cognition.Nature reviews. Neuroscience · 2022Review
- Anesthetic modulations dissociate neuroelectric characteristics between sensory-evoked and spontaneous activities across bilateral rat somatosensory cortical laminae.Scientific reports · 2022Article
- Microscale concert hall acoustics to produce uniform ultrasound stimulation for targeted sonogenetics in hsTRPA1-transfected cells.Advanced nanobiomed research · 2022Article
- Sensory computations in the cuneate nucleus of macaques.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Higher and deeper: Bringing layer fMRI to association cortex.Progress in neurobiology · 2021Review
- The brain and its time: intrinsic neural timescales are key for input processing.Communications biology · 2021Review
- Moving back in the brain to drive the field forward: Targeting neurostimulation to different brain regions in animal models of depression and neurodegeneration.Journal of neuroscience methods · 2021Article
- Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
During general anesthesia, global brain activity and behavioral state are profoundly altered. Yet it remains mostly unknown how anesthetics alter sensory processing across cortical layers and modulate functional cortico-cortical connectivity. To address this gap in knowledge of the micro- and mesoscale effects of anesthetics on sensory processing in the cortical microcircuit, we recorded multiunit activity and local field potential in awake and anesthetized ferrets (Mustela putoris furo) during sensory stimulation. To understand how anesthetics alter sensory processing in a primary sensory area and the representation of sensory input in higher-order association areas, we studied the local sensory responses and long-range functional connectivity of primary visual cortex (V1) and prefrontal cortex (PFC). Isoflurane combined with xylazine provided general anesthesia for all anesthetized recordings. We found that anesthetics altered the duration of sensory-evoked responses, disrupted the response dynamics across cortical layers, suppressed both multimodal interactions in V1 and sensory responses in PFC, and reduced functional cortico-cortical connectivity between V1 and PFC. Together, the present findings demonstrate altered sensory responses and impaired functional network connectivity during anesthesia at the level of multiunit activity and local field potential across cortical layers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.