ArticleInternational neurourology journal2015
Stress-Induced Depression Is Alleviated by Aerobic Exercise Through Up-Regulation of 5-Hydroxytryptamine 1A Receptors in Rats.
Article in International neurourology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Effects of Aerobic Exercise on Depressive Symptoms in People with Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Brain sciences · 2025Review
- A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters.Behavioral and brain functions : BBF · 2025Review
- Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions.Aging and disease · 2024Review
- Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity.International journal of molecular sciences · 2020Article
- Treadmill exercise ameliorates nicotine withdrawal-induced symptoms.Journal of exercise rehabilitation · 2019Article
- Treadmill exercise alleviates stress-induced anxiety-like behaviors in rats.Journal of exercise rehabilitation · 2018Article
- Treadmill exercise ameliorates depressive symptoms through increasing serotonin expression in postpartum depression rats.Journal of exercise rehabilitation · 2017Article
- Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.Endocrinology · 2016Article
- Postnatal Treadmill Exercise Alleviates Prenatal Stress-Induced Anxiety in Offspring Rats by Enhancing Cell Proliferation Through 5-Hydroxytryptamine 1A Receptor Activation.International neurourology journal · 2016Article
- Treadmill exercise alleviates stress-induced impairment of social interaction through 5-hydroxytryptamine 1A receptor activation in rats.Journal of exercise rehabilitation · 2015Article
- The rise of on-demand research and specific applications: optogenetics in urology.International neurourology journal · 2015Article
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Authors and funding
5 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeStress is associated with depression, which induces many psychiatric disorders. Serotonin, also known as 5-hydroxy-tryptamine (5-HT), acts as a biochemical messenger and regulator in the brain. It also mediates several important physiological functions. Depression is closely associated with an overactive bladder. In the present study, we investigated the effect of treadmill exercise on stress-induced depression while focusing on the expression of 5-HT 1A (5-H1A) receptors in the dorsal raphe.
methodsStress was induced by applying a 0.2-mA electric foot shock to rats. Each set of electric foot shocks comprised a 6-second shock duration that was repeated 10 times with a 30-second interval. Three sets of electric foot shocks were applied each day for 7 days. For the confirmation of depressive state, a forced swimming test was performed. To visualize the expression of 5-HT and tryptophan hydroxylase (TPH), immunohistochemistry for 5-HT and TPH in the dorsal raphe was performed. Expression of 5-H1A receptors was determined by western blot analysis.
resultsA depressive state was induced by stress, and treadmill exercise alleviated the depression symptoms in the stress-induced rats. Expressions of 5-HT, TPH, and HT 1A in the dorsal raphe were reduced by the induction of stress. Treadmill exercise increased 5-HT, TPH, and HT 1A expressions in the stress-induced rats.
conclusionsTreadmill exercise enhanced 5-HT synthesis through the up-regulation of 5-HT1A receptors, and improved the stress-induced depression. In the present study, treadmill exercise improved depression symptoms by enhancing 5-HT1A receptor expression. The present results suggest that treadmill exercise might be helpful for the alleviation of overactive bladder and improve sexual function.
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