ArticleMarine biotechnology (New York, N.Y.)2015
Potent Antifouling Marine Dihydroquinolin-2(1H)-one-Containing Alkaloids from the Gorgonian Coral-Derived Fungus Scopulariopsis sp.
Article in Marine biotechnology (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Trash or treasure? Unlocking dark matter of enantiomeric natural products in innovative drugs discovery for potent angiogenesis inhibitors.Marine life science & technology · 2026Article
- Marine-Derived Quinolinone CHNQD-00603 Triggers Autophagy via Suppressing the AKT/ERK/mTOR Pathway to Reverse Senescence and Restore Osteogenic Potential in Bone Marrow Mesenchymal Stem Cells.Current protein & peptide science · 2026Article
- Marine-Derived Yaequinolone Derivative CHNQD-02792 Suppresses Colorectal Cancer Cell Proliferation and Induces Apoptosis via MAPK Pathway Modulation.Marine drugs · 2025Article
- Marine endophytes: biosynthetic engines for novel bioactive metabolites.Frontiers in microbiology · 2025Review
- A comprehensive molecular phylogeny ofPersoonia · 2024Article
- New Insights on Biological Activities, Chemical Compositions, and Classifications of Marine Actinomycetes Antifouling Agents.Microorganisms · 2023Review
- Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities.Journal of fungi (Basel, Switzerland) · 2022Review
- Scalable total synthesis of (+)-aniduquinolone A and its acid-catalyzed rearrangement to aflaquinolones.Communications chemistry · 2022Article
- Anti-Larval and Anti-Algal Natural Products from Marine Microorganisms as Sources of Anti-Biofilm Agents.Marine drugs · 2022Review
- Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C-H Olefination.The Journal of organic chemistry · 2021Article
- Comprehensive Overview on the Chemistry and Biological Activities of Selected Alkaloid Producing Marine-Derived Fungi as a Valuable Reservoir of Drug Entities.Biomedicines · 2021Review
- Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration.Heliyon · 2021Review
- Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic FungusFrontiers in chemistry · 2021Article
- CHNQD-00603 Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by the miR-452-3p-Mediated Autophagy Pathway.Frontiers in cell and developmental biology · 2021Article
- Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products.Marine drugs · 2019Review
- Article
- Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor.Marine drugs · 2017Article
- Mini-Review: Antifouling Natural Products from Marine Microorganisms and Their Synthetic Analogs.Marine drugs · 2017Review
- Antifouling phenyl ethers and other compounds from the invertebrates and their symbiotic fungi collected from the South China Sea.AMB Express · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine biofouling has a major economic impact, especially when it occurs on ship hulls or aquaculture facilities. Since the International Maritime Organization (IMO) treaty to ban the application of organotin-based paints to ships went into effect in 2008, there is an urgent demand for the development of efficient and environmentally friendly antifouling agents. Marine microorganisms have proved to be a potential source of antifouling natural compounds. In this study, six dihydroquinolin-2-one-containing alkaloids, three monoterpenoids combined with a 4-phenyl-3,4-dihydroquinolin-2(1H)-one (1-3) and three 4-phenyl-3,4-dihydroquinolin-2(1H)-one alkaloids (4-6), were isolated from the gorgonian coral-derived fungus Scopulariopsis sp. collected in the South China Sea. These dihydroquinolin-2-one-containing alkaloids were evaluated against the larval settlement of barnacle Balanus amphitrite, and antifouling activity was detected for the first time for this class of metabolites. All of them except 6 showed strong antifouling activity. Compounds 1 and 2 were discovered to be the most promising non-toxic antilarval settlement candidates. Especially, compound 1 is the strongest antifouling compound in nature until now which showed highly potent activity with picomolar level (EC50 17.5 pM) and a very safety and high therapeutic ratio (LC50/EC50 1200). This represents an effective non-toxic, anti-larval settlement structural class of promising antifouling lead compound.
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