Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
95 citing papers in PubMed, 4 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures.Translational psychiatry · 2025Pooled it
- Peripheral endocannabinoids in major depressive disorder and alcohol use disorder: a systematic review.BMC psychiatry · 2024Pooled it
- Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, andFrontiers in pharmacology · 2024Pooled it
- The historical progression of positron emission tomography research in neuroendocrinology.Frontiers in neuroendocrinology · 2023Pooled it
- Sex differences in the acute effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC).Psychopharmacology · 2022Trial
- Brain imaging of cannabinoid type I (CBAddiction biology · 2021Trial
- Sex differences in the acute effects of smoked cannabis: evidence from a human laboratory study of young adults.Psychopharmacology · 2020Trial
- Endocannabinoid dynamics across marathon and ultramarathon running: evidence from two field studies.BMC medicine · 2026Article
- Anatomical white matter tracts span the cortical hierarchy to support cognitive diversity.Nature human behaviour · 2026Article
- Transdiagnostic alterations of intrinsic brain activity in major psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- The Neurochemical Orchestra of the Runner's High: A Narrative Review of Neuromodulatory Mechanisms with a Focus on Endocannabinoids.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026Review
- Distance-related functional connectivity alterations in first-episode, drug-naïve major depressive disorder: a resting-state fMRI study with atlas-based neurotransmitter correlates.BMC psychiatry · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Linking human brain functional connectivity to underlying neurotransmission.bioRxiv : the preprint server for biology · 2026Article
- Organization of neuropeptide systems in the human brain.Nature neuroscience · 2026Article
- Acute and delayed effects of THC on memories of stress in healthy adults.Psychopharmacology · 2026Article
- The Brain Endocannabinoid System is Differentially Regulated in Male and Female Patients with First-Episode Psychosis.Schizophrenia bulletin · 2026Article
- Cortical functional hierarchy disruption following subcortical stroke.BMC medicine · 2026Article
- Controlling the human connectome with spatially diffuse input signals.Communications biology · 2026Article
- An Interactive Brain Atlas of Knowledge.bioRxiv : the preprint server for biology · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
The Radiotracer [(11)C]OMAR was developed for positron emission tomography (PET) imaging of cannabinoid type-1 receptors (CB1R). The objectives of the present study were to evaluate kinetic analysis methods, determine test-retest reliability, and assess gender differences in receptor availability. Dynamic PET data were acquired in 10 human subjects, and analyzed with one-tissue (1T) and two-tissue (2T) compartment models and by the Logan and multilinear analysis (MA1) methods to estimate regional volume of distribution (VT). The 2T model inclusive of a vascular component (2TV) and MA1 were the preferred techniques. Test-retest reliability of VT was good (mean absolute deviation ~9%; intraclass correlation coefficient ~0.7). Tracer parent fraction in plasma was lower in women (P<0.0001). Cerebral uptake normalized by body weight and injected dose was higher in men by 17% (P<0.0001), but VT was significantly greater in women by 23% (P<0.0001). These findings show that [(11)C]OMAR binding can be reliably quantified by the 2T model or MA1 method and demonstrate the utility of this tracer for in vivo imaging of CB1R. In addition, results from the present study indicate that gender difference in receptor binding should be taken into consideration when [(11)C]OMAR is used to quantify CB1R availability in neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.