ArticleThe Lancet. Infectious diseases2015
Human infection with a novel tick-borne Anaplasma species in China: a surveillance study.
Article in The Lancet. Infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 4 of them syntheses that pooled it.
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Who cites it
153 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prevalence and associated factors of Anaplasma, Rickettsia, and Coxiella-related bacteria in ticks in China: A systematic review and meta-analysis.Experimental & applied acarology · 2026Pooled it
- Tick-Borne Diseases in Sub-Saharan Africa: A Systematic Review of Pathogens, Research Focus, and Implications for Public Health.Pathogens (Basel, Switzerland) · 2024Pooled it
- Human granulocytotropic anaplasmosis-A systematic review and analysis of the literature.PLoS neglected tropical diseases · 2024Pooled it
- Tick-borne zoonoses in the Order Rickettsiales and Legionellales in Iran: A systematic review.PLoS neglected tropical diseases · 2018Pooled it
- Detection of Anaplasma capra in Patients with Suspected Crimean-Congo Hemorrhagic Fever, Turkey, 2022.Emerging infectious diseases · 2026Review
- Global Trends in Vaccine Research onMicroorganisms · 2026Review
- Epidemiology and genetic evolution of Anaplasma species in rodents from southeastern China.Scientific reports · 2026Article
- Genetic Diversity and Novel Lineages ofPathogens (Basel, Switzerland) · 2026Article
- First report of 'Candidatus Anaplasma camelii' and high molecular prevalence of Anaplasma marginale in dromedary camels (Camelus dromedarius) from Somalia.Tropical animal health and production · 2026Article
- Comparative evaluation of oxytetracycline and an herbal formulation in the treatment of bovine anaplasmosis.Tropical animal health and production · 2026Article
- Application of LAMP and TaqMan qPCR for the rapid diagnosis of Anaplasma Capra (an emerging tick-borne zoonotic pathogen) and comparison with Nested-PCR.Veterinary research communications · 2026Article
- Article
- Research progress on emerging and important Tick-Borne pathogens.Frontiers in microbiology · 2026Review
- Molecular Diagnosis and Phylogenetic Analysis of Hemotropic Mycoplasmas andVeterinary medicine international · 2026Article
- Variety of Bacterial Pathogens in Ticks Removed from Humans, Northeastern China.Microorganisms · 2025Article
- Molecular characterization of livestock-associated ticks and tick-borne bacteria in Xinjiang, northwestern China.Parasites & vectors · 2025Article
- Genetic diversity and expanded epidemic area of novel tick-borne pathogen wetland virus in ticks, wild and domestic animals, and patient in China.Emerging microbes & infections · 2025Article
- Molecular detection of Anaplasma Capra and Anaplasma marginale in Rhipicephalus microplus ticks infesting cows.Scientific reports · 2025Article
- Bushmeat Consumption and the Risk of Zoonotic Tick-Borne Pathogen Infections in Ghana: An Increasing Risk to Public Health.Public health challenges · 2025Article
- Molecular Characterization of Tick-Borne Pathogens in Jiangxi Province: A High Prevalence ofPathogens (Basel, Switzerland) · 2025Article
93 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors.
Funding
Abstract
backgroundAnaplasma phagocytophilum and Anaplasma ovis cause human infections. We investigated the potential for human pathogenicity of a newly discovered Anaplasma species infecting goats in China.
methodsWe collected blood samples from patients with a history of tick bite in the preceding 2 months at Mudanjiang Forestry Central Hospital of Heilongjiang Province from May 1, to June 10, 2014, to detect the novel Anaplasma species by PCR. We inoculated positive samples into cell cultures. We characterised the isolated pathogen by morphological and phylogenetic analyses. We tested serum antibodies by indirect immunofluorescence assay.
findings28 (6%) of 477 patients assessed were infected with the novel Anaplasma species according to PCR and sequencing. We isolated the pathogen in vitro from three patients. Phylogenetic analyses of rrs, gltA, groEL, msp2, and msp4 showed that the pathogen was distinct from all known Anaplasma species. We provisionally nominate it "Anaplasma capra". 22 (92%) of 24 patients with data available had seroconversion or a four-fold increase in antibody titres. All 28 patients developed non-specific febrile manifestations, including fever in 23 (82%), headache in 14 (50%), malaise in 13 (46%), dizziness in nine (32%), myalgia in four (14%), and chills in four (14%). Additionally, ten (36%) of 28 patients had rash or eschar, eight (29%) had lymphadenopathy, eight (29%) had gastrointestinal symptoms, and three (11%) had stiff neck. Five patients were admitted to hospital because of severe disease. Six (35%) of 17 patients with data available had high hepatic aminotransferase concentrations.
interpretationThe emergence of "A capra" as a cause of human disease suggests that individuals living in or travelling to endemic regions in northern China should take precautions to reduce their risk of exposure to this novel tick-borne pathogen.
fundingNatural Science Foundation of China and the US National Institutes of Health.
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