ArticleVirus genes2015
Molecular detection of hepatitis E virus in sheep from southern Xinjiang, China.
Article in Virus genes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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The trial behind it
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Pooled it
- Prevalence of hepatitis E virus in domestic animals in the Chinese mainland: a systematic review and meta-analysis.BMC veterinary research · 2025Pooled it
- Hepatitis E Virus in the Iberian Peninsula: A Systematic Review.Food and environmental virology · 2023Pooled it
- Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis.BMC veterinary research · 2021Pooled it
- Elevated risk of hepatitis E virus infection among sheep smallholders in Xinjiang, China.One health (Amsterdam, Netherlands) · 2026Article
- Detection and Characterization ofPathogens (Basel, Switzerland) · 2025Article
- Trends and Challenges in the Detection and Environmental Surveillance of the Hepatitis E Virus.Microorganisms · 2025Review
- Hepatitis E Virus in the Role of an Emerging Food-Borne Pathogen.Microorganisms · 2025Review
- First Insight into the Seroprevalence of Hepatitis E Virus and Associated Risk Factors Among Liver Transplant Recipients from Bulgaria.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2025Article
- Serological and Molecular Survey of Hepatitis E Virus in Small Ruminants from Central Portugal.Food and environmental virology · 2024Article
- Article
- Hepatitis E Virus in Domestic Ruminants and Virus Excretion in Milk-A Potential Source of Zoonotic HEV Infection.Viruses · 2024Review
- No evidence of hepatitis E virus (HEV) infection among pet cats and dogs, and low seroprevalence of hepatitis E virus among pet rabbits in Poland.Veterinary research communications · 2024Article
- Hepatitis E Virus in Livestock-Update on Its Epidemiology and Risk of Infection to Humans.Animals : an open access journal from MDPI · 2023Review
- Article
- Hepatitis E Virus (HEV) Infection among Humans and Animals: Epidemiology, Clinical Characteristics, Treatment, and Prevention.Pathogens (Basel, Switzerland) · 2023Article
- A Systematic Review and Meta-Analysis on Hepatitis E Virus Detection in Farmed Ruminants.Pathogens (Basel, Switzerland) · 2023Review
- Hepatitis E Virus (HEV) Spreads from Pigs and Sheep in Mongolia.Animals : an open access journal from MDPI · 2023Article
- Detection of Hepatitis E Virus Genotype 3 in Feces of Capybaras (Hydrochoeris hydrochaeris) in Brazil.Viruses · 2023Article
- Is Hepatitis E Virus a Neglected or Emerging Pathogen in Egypt?Pathogens (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis E virus (HEV) is a causative agent of infectious hepatitis in animals and humans both in developing and developed countries. Here, we collected 500 sheep sera and 75 raw sheep liver samples from a slaughterhouse in the southern part of the Xinjiang region, China, along with 26 sera of butchers from the same slaughterhouse. All serum samples were tested for anti-HEV antibody by enzyme-linked immunosorbent assay. Both serum and liver samples were evaluated for the presence of HEV RNA by nested polymerase chain reaction targeting partial nucleotide sequences of open reading frame 2 (ORF2). The results indicate that sheep seroprevalence was 35.20 % (176/500) and that four of the 75 (5.3 %) sheep livers showed detectable amounts of HEV RNA. The seroprevalence of the butchers was 57.7 % (15/26). The four amplicons shared 97.8-100 % nucleotide sequence identity and had pairwise sequence identities of 81.6-85.3 %, 84.2-85.3 %, 82.1-85.3 % and 84.7-97.9 % with the corresponding regions of genotypes 1, 2, 3 and 4 of HEV, respectively. A phylogenetic tree was constructed based on alignments of an amplified 186-bp ORF2 sequence and corresponding reference strains. The analysis showed that the four sheep strains detected in our study formed a lineage within a genotype 4 cluster that contains hb-3, bjsw1, T1, swCH189 and swCH25, all of which belong to genotype 4, subtype 4d. The results indicated a high level of seroconversion in sheep and suggested that sheep liver may be a source of foodborne HEV infection in humans.
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