ArticleInternational journal of legal medicine2016
A single-tube 27-plex SNP assay for estimating individual ancestry and admixture from three continents.
Article in International journal of legal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Efficiency of Ancestral Inference and Characterization of Genetic Structure of Chinese Kazakh Group with a Novel InDel Panel.Journal of molecular evolution · 2025Article
- Forensic skeletal and molecular anthropology face to face: Combining expertise for identification of human remains.Annals of the New York Academy of Sciences · 2025Review
- Ancestral Information Analysis of Chinese Korean Ethnic Group via a Novel Multiplex DIP System.Journal of molecular evolution · 2023Article
- Special Issue "Forensic Genetics and Genomics".Genes · 2021Article
- Development and Performance Evaluation of a Novel Ancestry Informative DIP Panel for Continental Origin Inference.Frontiers in genetics · 2021Article
- Next generation sequencing of a set of ancestry-informative SNPs: ancestry assignment of three continental populations and estimating ancestry composition for Mongolians.Molecular genetics and genomics : MGG · 2020Article
- Article
- Ancestry inference and admixture component estimations of Chinese Kazak group based on 165 AIM-SNPs via NGS platform.Journal of human genetics · 2020Article
- An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data.BMC genomics · 2019Article
- Exploring the ancestry differentiation and inference capacity of the 28-plex AISNPs.International journal of legal medicine · 2019Article
- Twenty-seven continental ancestry-informative SNP analysis of bone remains to resolve a forensic case.Forensic sciences research · 2019Article
- A panel of 130 autosomal single-nucleotide polymorphisms for ancestry assignment in five Asian populations and in Caucasians.Forensic science, medicine, and pathology · 2017Article
- Massively parallel sequencing of 231 autosomal SNPs with a custom panel: a SNP typing assay developed for human identification with Ion Torrent PGM.Forensic sciences research · 2017Article
- Genetic structure and differentiation analysis of a Eurasian Uyghur population by use of 27 continental ancestry-informative SNPs.International journal of legal medicine · 2016Article
- [Efficiency of 27-plex single nucleotide polymorphism multiplex system for ancestry inference in different populations].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2016Article
- Selection of highly informative SNP markers for population affiliation of major US populations.International journal of legal medicine · 2016Article
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11 authors.
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Abstract
A single-tube multiplex assay of a small set of ancestry-informative markers (AIMs) for effectively estimating individual ancestry and admixture is an ideal forensic tool to trace the population origin of an unknown DNA sample. We present a newly developed 27-plex single nucleotide polymorphism (SNP) panel with highly robust and balanced differential power to perfectly assign individuals to African, European, and East Asian ancestries. Evaluating 968 previously described intercontinental AIMs from three HapMap population genotyping datasets (Yoruban in Ibadan, Nigeria (YRI); Utah residents with Northern and Western European ancestry from the Centre de'Etude du Polymorphism Humain (CEPH) collection (CEU); and Han Chinese in Beijing, China (CHB)), the best set of markers was selected on the basis of Hardy-Weinberg equilibrium (p > 0.00001), population-specific allele frequency (two of three δ values >0.5), according to linkage disequilibrium (r (2) < 0.2), and capable of being multiplexed in one tube and detected by capillary electrophoresis. The 27-SNP panel was first validated by assigning the ancestry of the 11 populations in the HapMap project. Then, we tested the 27-plex SNP assay with 1164 individuals from 17 additional populations. The results demonstrated that the SNP panel was successful for ancestry inference of individuals with African, European, and East Asian ancestry. Furthermore, the system performed well when inferring the admixture of Eurasians (EUR/EAS) after analyzing admixed populations from Xinjiang (Central Asian) as follows: Tajik (68:27), Uyghur (49:46), Kirgiz (40:57), and Kazak (36:60). For individual analyses, we interpreted each sample with a three-ancestry component percentage and a population match probability sequence. This multiplex assay is a convenient and cost-effective tool to assist in criminal investigations, as well as to correct for the effects of population stratification for case-control studies.
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