ArticleHuman brain mapping2015
Age and sex effects on corpus callosum morphology across the lifespan.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Sex differences in brain homotopic co-activations: a meta-analytic study.Brain structure & function · 2022Pooled it
- Structural, Functional, and Metabolic Brain Differences as a Function of Gender Identity or Sexual Orientation: A Systematic Review of the Human Neuroimaging Literature.Archives of sexual behavior · 2021Pooled it
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- Assessment of Sports Concussion in Female Athletes: A Role for Neuroinformatics?Neuroinformatics · 2024Review
- Ideational Slippage in Middle-Aged and Older Adults: A Preliminary Study.International journal of environmental research and public health · 2024Article
- Pain mechanisms in the transgender individual: a review.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria.The Libyan journal of medicine · 2023Article
- A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients.Journal of anatomy · 2023Article
- Individual variability in the nonlinear development of the corpus callosum during infancy and toddlerhood: a longitudinal MRI analysis.Brain structure & function · 2022Article
- Article
- Alterations in brain morphology by MRI in adults with neurofibromatosis 1.Orphanet journal of rare diseases · 2021Article
- Comparative morphology of the corpus callosum across the adult lifespan in chimpanzees (Pan troglodytes) and humans.The Journal of comparative neurology · 2021Article
- Diffusion abnormalities in the corpus callosum in first episode schizophrenia: Associated with enlarged lateral ventricles and symptomatology.Psychiatry research · 2019Article
- Brain Differences Between Men and Women: Evidence From Deep Learning.Frontiers in neuroscience · 2019Article
- Anterior to Midposterior Corpus Callosum Subregions Are Volumetrically Reduced in Male Alcoholics but Only the Anterior Segment Is Associated to Alcohol Use.Frontiers in psychiatry · 2019Article
- Observational
- Corpus callosum volumes in the 5 years following the first-episode of schizophrenia: Effects of antipsychotics, chronicity and maturation.NeuroImage. Clinical · 2018Article
- Ethnicity Influences Corpus Callosum Dimensions.Neurology research international · 2018Article
- Sex-specific effects ofBrain and behavior · 2017Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
The corpus callosum (CC) is the largest interhemispheric white matter tract in the human brain, and is characterized by pronounced differences in morphology among individuals. There are limited data, however, regarding typical development, sex differences, and the neuropsychological correlates of individual differences within CC subregions. Magnetic resonance (MR) imaging exams were collected in a large cohort (N = 305) of healthy individuals (ages 8-68). We used a highly reliable program to automatically identify the midsagittal plane and obtain CC subregion measures according to approaches described by Witelson [1989]: Brain 112:799-835 and Hampel et al. [1998]: Arch Neurol 55:193-198 and a measure of whole CC shape (i.e., circularity). CC measurement parameters, including area, perimeter, length, circularity, and CC subregion area values were generally characterized by inverted U-shaped curves across the observed age range. Peak values for CC subregions were observed between ages 32 and 45, and descriptive linear correlations were consistent with sharper area changes in development. We also observed differing age-associated changes across the lifespan between males and females in the CC subregion corresponding to the genu (Witelson's subregion 2), as well as CC circularity. Mediation analysis using path modeling indicated that genu area mediated the relationship between age and processing speed for females, and the relationship between age and visual learning and executive functioning for males. Taken together, our findings implicate sex differences in CC morphology across the lifespan that are localized to the genu, which appear to mediate neuropsychological functions.
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Registered trials
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