Observational studyInternational journal of clinical pharmacy2015
Drug utilisation profile in the neonatal unit of a university hospital: a prospective observational study in Brazil.
Observational study in International journal of clinical pharmacy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Drug Utilisation and Off-Label Use on a German Neonatal Intensive Care Unit: A Retrospective Cohort Study and 10-Year Comparison.Pharmacy (Basel, Switzerland) · 2020Article
- Review of Drug Utilization Studies in Neonatal Units: A Global Perspective.International journal of environmental research and public health · 2020Review
- Impact of preterm birth and low birth weight on medical conditions, medication use and mortality among neonates: a prospective observational cohort study.World journal of pediatrics : WJP · 2019Observational
- Variation of the prevalence of pediatric polypharmacy: A scoping review.Pharmacoepidemiology and drug safety · 2019Article
- Defining pediatric polypharmacy: A scoping review.PloS one · 2018Article
- Pattern of drug use among preterm neonates: results from an Italian neonatal intensive care unit.Italian journal of pediatrics · 2017Article
- Drug Utilization on Neonatal Wards: A Systematic Review of Observational Studies.Frontiers in pharmacology · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvances in neonatology have contributed to changes in the drug utilisation profile in neonates, both in the number of drugs and the pharmacotherapeutic groups.
objectiveTo analyse drug use in the neonatal care unit of a teaching hospital in Brazil and to evaluate the associations among perinatal, clinical care and drug use data.
settingThe neonatal care unit of a teaching hospital in Brazil.
methodsA prospective observational study was conducted. Perinatal, clinical care and pharmacotherapy data were collected from the patients' medical records. Labelling information regarding neonatal use was analysed for prescribed drugs. The data were analysed using univariate descriptive statistics and quasi-Poisson regression.
main outcome measureFrequency of drug use by gestational age.
resultsThe study included 187 patients; 157 (84.0 %) received drugs. The mean gestational age was 35.8 weeks. The mean number of drugs prescribed per patient was 6.4. The number of drugs used was inversely correlated to gestational age and birth weight. The most commonly prescribed drugs belonged to the following anatomical therapeutic chemical groups: nervous system drugs, anti-infectives for systemic use, and alimentary tract and metabolism drugs. Information regarding neonatal use was given in the labelling of only 20.5 % of the prescribed drugs. Of these, only 9.5 % had information specific for preterm infants.
conclusionsDrug administration to neonates is frequently and inversely correlated to gestational age and birth weight. Neonates are exposed to different therapeutic classes, reflecting scientific advances in neonatology. In Brazil, the percentage of drugs with neonate-specific labelling information is low. Consequently, there is an evident need for efforts to guarantee effective and safe pharmacotherapy for neonates.
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