ArticleJournal of gastrointestinal cancer2015
Visceral Adiposity is a Risk Factor for Poor Prognosis in Colorectal Cancer Patients Receiving Adjuvant Chemotherapy.
Article in Journal of gastrointestinal cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Impact of visceral obesity on postoperative outcomes in colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- Adiposity and cancer survival: a systematic review and meta-analysis.Cancer causes & control : CCC · 2022Pooled it
- Adipocytes as Orchestrators of Multimodal Cancer Therapy Resistance.Biomolecules & therapeutics · 2026Review
- Effect of Liraglutide on Intermittent Hypoxia-Induced Metabolic Dysfunction: From Bench to Bedside.Journal of sleep research · 2026Article
- Impact of visceral fat distribution on postoperative complications in high-aged patients undergoing gastric cancer surgery: A cross-sectional study.World journal of gastroenterology · 2025Article
- Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer.World journal of gastrointestinal oncology · 2025Article
- Improving the prediction of chemotherapy dose-limiting toxicity in colon cancer patients using an AI-CT-based 3D body composition of the entire L1-L5 lumbar spine.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Can AI-based body composition assessment outperform body surface area in predicting dose-limiting toxicities for colonic cancer patients on chemotherapy?Journal of cancer research and clinical oncology · 2023Article
- Role of Perirectal Fat in the Carcinogenesis and Development of Early-Onset Rectal Cancer.Journal of oncology · 2022Article
- Body Composition, Inflammation, and 5-Year Outcomes in Colon Cancer.JAMA network open · 2021Article
- Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases.Journal of cachexia, sarcopenia and muscle · 2021Article
- The effect of smoking, obesity and diabetes on recurrence-free and overall survival in patients with stage III colon cancer receiving adjuvant chemotherapy.Cancer reports (Hoboken, N.J.) · 2021Article
- Article
- Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study.Cancer causes & control : CCC · 2020Article
- Association of adipose tissue and skeletal muscle metrics with overall survival and postoperative complications in soft tissue sarcoma patients: an opportunistic study using computed tomography.Quantitative imaging in medicine and surgery · 2020Article
- Lipid-Based Drug Delivery Nanoplatforms for Colorectal Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2020Review
- The Association of Abdominal Adiposity With Mortality in Patients With Stage I-III Colorectal Cancer.Journal of the National Cancer Institute · 2020Article
- Left ventricular myocardial deformation: a study on diastolic function in the Chinese male population and its relationship with fat distribution.Quantitative imaging in medicine and surgery · 2020Article
- Is visceral obesity associated with colorectal cancer? The first volumetric study using all CT slices.Diagnostic and interventional radiology (Ankara, Turkey) · 2019Article
- Impact of genetic mutations and nutritional status on the survival of patients with colorectal cancer.BMC cancer · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies utilizing body mass index (BMI) have failed to show a consistent relationship between obesity and survival following treatment for colorectal cancer (CRC). Computerized tomography (CT) offers a reliable alternative approach to quantify body adiposity. We hypothesized that visceral obesity may negatively impact survival in CRC patients. AIMS AND
methodsA retrospective review of CRC patients who received adjuvant chemotherapy at a single center during the period 2006-2009 identified from a prospectively maintained database. Visceral adiposity was determined by measuring visceral fat area (VFA) on preoperative staging CT. All patients were followed up to study completion or death.
resultsSixty-two CRC patients with a mean age of 63.2 years received adjuvant chemotherapy and had imaging available for analysis. Thirty-five patients (56.5 %) had node positive disease. Thirty-one patients (50 %) were classified viscerally obese based on staging CT. 85.4 % of the patients completed adjuvant chemotherapy and visceral obesity was not associated with increased toxicity or failure to complete treatment. After a median follow-up of 65.2 months, patients with visceral obesity had a significantly lower overall survival (OS) (54.8 % vs 87.1 %, p = 0.004) and disease-free survival (DFS) (48.4 vs 77.4 %, p = 0.007) compared with patients without visceral obesity. There was no relationship between BMI and survival. Multivariate analysis using Cox proportional hazards model showed that visceral obesity was independently associated with reduced OS (Hazard ratio = 7.0; 95 % CI 2.0-24.6; p = 0.002).
conclusionThis study shows that visceral obesity increases the likelihood of a poor prognosis in CRC patients receiving adjuvant chemotherapy thus underlying the value of lifestyle interventions to minimize visceral obesity in this patient cohort.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.