ArticleNature2015
PLD3 in non-familial Alzheimer's disease.
Open access · greenAbstract readLetterComment
In one paragraph
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- ABCA7 rare variants and Alzheimer disease risk.Neurology · 2016Pooled it
- The lysosomal catabolism of nucleic acids-critical regulators of the innate immune system.Nucleic acids research · 2025Review
- Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions.The FEBS journal · 2024Article
- PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.Cell · 2024Article
- Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.Structure (London, England : 1993) · 2024Article
- PLD3 and PLD4 synthesizebioRxiv : the preprint server for biology · 2024Article
- Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.Nucleic acids research · 2024Article
- Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease.Molecular neurodegeneration · 2022Review
- PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.PLoS genetics · 2021Article
- Lipids and Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules.Biomolecules · 2020Review
- The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.Cell reports · 2019Article
- Benefits and Challenges of Rare Genetic Variation in Alzheimer's Disease.Current genetic medicine reports · 2019Article
- Phosphatidic Acid: From Pleiotropic Functions to Neuronal Pathology.Frontiers in cellular neuroscience · 2019Review
- Article
- The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- PLD3 epigenetic changes in the hippocampus of Alzheimer's disease.Clinical epigenetics · 2018Article
- PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.Nature immunology · 2018Article
- Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.Cellular and molecular life sciences : CMLS · 2018Article
- Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2018Review
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Authors and funding
32 authors at 14 institutions in 3 countries.
Stefanie Heilmann1] Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany [2] Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany.
Dmitriy DrichelGerman Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Jordi Clarimon1] Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital Santa Creu i Sant Pau, Autonomous University Barcelona, 08025 Barcelona, Spain [2] Center for Networking Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain.
Victoria FernándezMemory Clinic of Fundaciò ACE, Catalan Institute of Applied Neurosciences, 08028 Barcelona, Spain.
André LacourGerman Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Holger WagnerDepartment of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Mathias ThelenDepartment of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Isabel HernándezMemory Clinic of Fundaciò ACE, Catalan Institute of Applied Neurosciences, 08028 Barcelona, Spain.
Juan Fortea1] Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital Santa Creu i Sant Pau, Autonomous University Barcelona, 08025 Barcelona, Spain [2] Center for Networking Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain.
Montserrat AlegretMemory Clinic of Fundaciò ACE, Catalan Institute of Applied Neurosciences, 08028 Barcelona, Spain.
Rafael Blesa1] Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital Santa Creu i Sant Pau, Autonomous University Barcelona, 08025 Barcelona, Spain [2] Center for Networking Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain.
Ana MauleónMemory Clinic of Fundaciò ACE, Catalan Institute of Applied Neurosciences, 08028 Barcelona, Spain.
Maitée Rosende RocaMemory Clinic of Fundaciò ACE, Catalan Institute of Applied Neurosciences, 08028 Barcelona, Spain.
Johannes KornhuberDepartment of Psychiatry and Psychotherapy, University Clinic Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Oliver PetersDepartment of Psychiatry, Charité University Medicine, 14050 Berlin, Germany.
Reinhard HeunDepartment of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Lutz FrölichDepartment of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Michael HüllCentre for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology, Medical School, University of Freiburg, 79106 Freiburg, Germany.
Michael T Heneka1] German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany [2] Clinical Neuroscience Unit, Department of Neurology, University of Bonn, 53127 Bonn, Germany.
Eckart RütherDepartment of Psychiatry and Psychotherapy, University of Göttingen, 37075 Göttingen, Germany.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103 Leipzig, Germany.
Martin SchererDepartment of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University of Göttingen, 37075 Göttingen, Germany.
Frank Jessen1] German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany [2] Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany [3] Department of Psychiatry and Psychotherapy, University of Cologne, 50937 Cologne, Germany.
Tim Becker1] German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany [2] Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, 53127 Bonn, Germany.
Lluís TárragaMemory Clinic of Fundaciò ACE, Catalan Institute of Applied Neurosciences, 08028 Barcelona, Spain.
Mercè BoadaMemory Clinic of Fundaciò ACE, Catalan Institute of Applied Neurosciences, 08028 Barcelona, Spain.
Wolfgang Maier1] German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany [2] Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Alberto Lleó1] Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital Santa Creu i Sant Pau, Autonomous University Barcelona, 08025 Barcelona, Spain [2] Center for Networking Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain.
Agustin RuizMemory Clinic of Fundaciò ACE, Catalan Institute of Applied Neurosciences, 08028 Barcelona, Spain.
Markus M Nöthen1] Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany [2] Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany.
Alfredo Ramirez1] Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany [2] Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
Fundació ACE · ESUniversity of Bonn · DEGerman Center for Neurodegenerative Diseases · DEBiomedical Research Institute · USBiomedical Research Networking Center on Neurodegenerative Diseases · ESCharité - Universitätsmedizin Berlin · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHeidelberg University · DEHospital de Sant Pau · ESLeipzig University · DEUniversität Hamburg · DEUniversitätsmedizin Göttingen · DEUniversity Medical Center Freiburg · DEUniversity of Göttingen · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Alzheimer DiseaseFemaleGenetic Predisposition to DiseaseGenetic VariationHumansMalePhospholipase DPhospholipase D
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.