Evidence map›Paper›PMID 25832238›Full record

ArticleThe Review of scientific instruments2015

Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy.

Jesse W Wilson, Jong Kang Park, Warren S Warren, Martin C Fischer

Abstract readComparative Study
In one paragraph

Article in The Review of scientific instruments, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Leaving the Limits of Linearity for Light Microscopy.The journal of physical chemistry. C, Nanomaterials and interfaces · 2020
    Article
  2. Article
  3. Invited Review Article: Pump-probe microscopy.The Review of scientific instruments · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jesse W WilsonDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.
Jong Kang ParkDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.
Warren S WarrenDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.
Martin C FischerDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.

Funding

Improving Melanoma Diagnosis with Pump-Probe Optical ImagingR01CA166555 · NCI · DUKE UNIVERSITY · PI WARREN, WARREN S · 2013 to 2017
$1.6M
Novel Techniques in Nonlinear Optical Microscopy for Improving Melanoma DiagnosisF32CA168497 · NCI · DUKE UNIVERSITY · PI WILSON, JESSE WILLIAM · 2013 to 2015
$129k
NCI NIH HHS F32 CA168497NCI NIH HHS F32CA168497NCI NIH HHS R01 CA166555NCI NIH HHS R01CA166555
6 · The paper itself

Abstract

The lock-in amplifier is a critical component in many different types of experiments, because of its ability to reduce spurious or environmental noise components by restricting detection to a single frequency and phase. One example application is pump-probe microscopy, a multiphoton technique that leverages excited-state dynamics for imaging contrast. With this application in mind, we present here the design and implementation of a high-speed lock-in amplifier on the field-programmable gate array (FPGA) coprocessor of a data acquisition board. The most important advantage is the inherent ability to filter signals based on more complex modulation patterns. As an example, we use the flexibility of the FPGA approach to enable a novel pump-probe detection scheme based on spread-spectrum communications techniques.

Indexed as

AnimalsEquipment DesignImaging, Three-DimensionalMelaninsMice, Inbred C57BLMicroscopyOptical ImagingPorphyrinsRhodaminesSignal Processing, Computer-AssistedSignal-To-Noise RatioSkinSpectrum AnalysisMelaninsPorphyrinsrhodamine 6GRhodamines

Identifiers

PMID25832238
PMCPMC4385102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.