Evidence map›Paper›PMID 25832087›Full record

ArticleMedical physics2015

Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam.

Matthew D Belley, Ian N Stanton, Mike Hadsell, Rachel Ger, Brian W Langloss, Jianping Lu, Otto Zhou, Sha X Chang, Michael J Therien, Terry T Yoshizumi

Open access · greenAbstract read
In one paragraph

Article in Medical physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Matthew D BelleyMedical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 and Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710.
Ian N StantonDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708.
Mike HadsellDepartment of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599.
Rachel GerDepartment of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599.
Brian W LanglossDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708.
Jianping LuDepartment of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599.
Otto ZhouDepartment of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599 and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599.
Sha X ChangDepartment of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599; Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599; and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599.
Michael J TherienDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708.
Terry T YoshizumiMedical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705;Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710; and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
University of North Carolina at Chapel Hill · USDuke University · USDuke Medical Center · US

Funding

Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
Translational Nanosystems for Improved Lung Cancer Treatment with Small MoleculesU54CA151652 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DESIMONE, JOSEPH M. · 2010 to 2014
$12.1M
NCI NIH HHS U54 CA151652NCI NIH HHS U54-CA151652NIAID NIH HHS 5U19AI067798NIAID NIH HHS U19 AI067798
6 · The paper itself

Abstract

purposeHere, the authors describe a dosimetry measurement technique for microbeam radiation therapy using a nanoparticle-terminated fiber-optic dosimeter (nano-FOD).

methodsThe nano-FOD was placed in the center of a 2 cm diameter mouse phantom to measure the deep tissue dose and lateral beam profile of a planar x-ray microbeam.

resultsThe continuous dose rate at the x-ray microbeam peak measured with the nano-FOD was 1.91 ± 0.06 cGy s(-1), a value 2.7% higher than that determined via radiochromic film measurements (1.86 ± 0.15 cGy s(-1)). The nano-FOD-determined lateral beam full-width half max value of 420 μm exceeded that measured using radiochromic film (320 μm). Due to the 8° angle of the collimated microbeam and resulting volumetric effects within the scintillator, the profile measurements reported here are estimated to achieve a resolution of ∼0.1 mm; however, for a beam angle of 0°, the theoretical resolution would approach the thickness of the scintillator (∼0.01 mm).

conclusionsThis work provides proof-of-concept data and demonstrates that the novel nano-FOD device can be used to perform real-time dosimetry in microbeam radiation therapy to measure the continuous dose rate at the x-ray microbeam peak as well as the lateral beam shape.

Indexed as

RadiotherapyX-Ray TherapyAnimalsCalibrationEquipment DesignFiber Optic TechnologyMiceMicroscopy, Electron, ScanningNanoparticlesPhantoms, ImagingRadiometryX-Rays

Identifiers

PMID25832087
PMCPMC4376762
OpenAlexW2073548263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.