ArticleProceedings of the National Academy of Sciences of the United States of America2015
Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 68 citations in OpenAlex.
- Multiscale biomimetic design for peripheral nerve repair: Beyond passive bridging.Materials today. Bio · 2026Review
- Materiobiology in the omics era.Materials today. Bio · 2025Review
- Human bone marrow derived stem cell differentiation on 3D printed bioactive glass scaffolds.Journal of materials science. Materials in medicine · 2025Article
- Evaluating pathological levels of intracellular cholesterol through Raman and surface-enhanced Raman spectroscopies.Scientific reports · 2024Article
- Molecular Fingerprinting of Mouse Brain Using Ultrabroadband Coherent Anti-Stokes Raman Scattering (CARS) Microspectroscopy Empowered by Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS).Chemical & biomedical imaging · 2024Article
- Effect of BiosilicateJournal of functional biomaterials · 2023Article
- Potential bioactive coating system for high-performance absorbable magnesium bone implants.Bioactive materials · 2022Review
- The Clinical Significance and Immunization of MSMO1 in Cervical Squamous Cell Carcinoma Based on Bioinformatics Analysis.Frontiers in genetics · 2021Article
- A biomimetic engineered bone platform for advanced testing of prosthetic implants.Scientific reports · 2020Article
- Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- QSAR without borders.Chemical Society reviews · 2020Review
- NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools forComputational and structural biotechnology journal · 2020Review
- Osteogenic potential of sol-gel bioactive glasses containing manganese.Journal of materials science. Materials in medicine · 2019Article
- Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass.Biomaterials · 2019Article
- A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair.Dental materials : official publication of the Academy of Dental Materials · 2019Article
- Cellular Response to 3-D Printed Bioactive Silicate and Borosilicate Glass Scaffolds.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Quantitative design rules for protein-resistant surface coatings using machine learning.Scientific reports · 2019Article
- Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Sparse QSAR modelling methods for therapeutic and regenerative medicine.Journal of computer-aided molecular design · 2018Review
- Cobalt-containing bioactive glasses reduce human mesenchymal stem cell chondrogenic differentiation despite HIF-1α stabilisation.Journal of the European Ceramic Society · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
Despite the increasing sophistication of biomaterials design and functional characterization studies, little is known regarding cells' global response to biomaterials. Here, we combined nontargeted holistic biological and physical science techniques to evaluate how simple strontium ion incorporation within the well-described biomaterial 45S5 bioactive glass (BG) influences the global response of human mesenchymal stem cells. Our objective analyses of whole gene-expression profiles, confirmed by standard molecular biology techniques, revealed that strontium-substituted BG up-regulated the isoprenoid pathway, suggesting an influence on both sterol metabolite synthesis and protein prenylation processes. This up-regulation was accompanied by increases in cellular and membrane cholesterol and lipid raft contents as determined by Raman spectroscopy mapping and total internal reflection fluorescence microscopy analyses and by an increase in cellular content of phosphorylated myosin II light chain. Our unexpected findings of this strong metabolic pathway regulation as a response to biomaterial composition highlight the benefits of discovery-driven nonreductionist approaches to gain a deeper understanding of global cell-material interactions and suggest alternative research routes for evaluating biomaterials to improve their design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.