ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2015
Dynamic resistance training decreases sympathetic tone in hypertensive ovariectomized rats.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Physical Exercise Effects on Cardiovascular Autonomic Modulation in Postmenopausal Women-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Pooled it
- A characterization of dynamic resistance training-induced skeletal muscle adaptations in hypertensive rats.Physiological reports · 2025Article
- Preventive Effects of Resistance Training on Hemodynamics and Kidney Mitochondrial Bioenergetic Function in Ovariectomized Rats.International journal of molecular sciences · 2024Article
- Strength training improves heart function, collagen and strength in rats with heart failure.The journal of physiological sciences : JPS · 2024Article
- Hypertension after the Menopause: What Can We Learn from Experimental Studies?Physiological research · 2023Review
- Combined Exercise Training Promotes More Benefits on Cardiovascular Autonomic Modulation in Ovariectomized Rats Than Isolated Aerobic or Resistance Training.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Effect of blood flow-restricted resistance training on myocardial fibrosis in early spontaneously hypertensive rats.Frontiers in cardiovascular medicine · 2023Article
- The Effect of Blood Flow-Restricted Low Resistance Training on Microvascular Circulation of Myocardium in Spontaneously Hypertensive Rats.Frontiers in physiology · 2022Article
- Resistance training improves cardiac function and cardiovascular autonomic control in doxorubicin-induced cardiotoxicity.Cardiovascular toxicology · 2021Article
- Familial history of hypertension-induced impairment on heart rate variability was not observed in strength-trained subjects.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Cardiovascular Benefits of Exercise Training in Postmenopausal Hypertension.International journal of molecular sciences · 2018Review
- Non-periodized and Daily Undulating Periodized Resistance Training on Blood Pressure of Older Women.Frontiers in physiology · 2018Article
- Combined Aerobic and Resistance Exercise Training Improve Hypertension Associated With Menopause.Frontiers in physiology · 2018Article
- Resistance Training in Spontaneously Hypertensive Rats with Severe Hypertension.Arquivos brasileiros de cardiologia · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effects of resistance exercise training on hemodynamics and cardiac autonomic control in ovariectomized spontaneously hypertensive rats. Female rats were divided into 4 groups: sedentary control (SC), sedentary hypertensive (SH), sedentary hypertensive ovariectomized (SHO), and resistance-trained hypertensive ovariectomized (RTHO). Resistance exercise training was performed on a vertical ladder (5 days/week, 8 weeks) at 40-60% maximal load. Direct arterial pressure was recorded. Vagal and sympathetic tones were measured by heart rate (HR) responses to methylatropine (3 mg/kg, iv) and propranolol (4 mg/kg, iv). Ovariectomy resulted in additional increases in blood pressure in hypertensive rats and was associated with decreased vagal tone. Resistance exercise trained rats had lower mean arterial pressure than untrained rats (RTHO: 159±2.2 vs SHO: 177±3.4 mmHg), as well as resting bradycardia (RTHO: 332±9.0 vs SHO: 356±5 bpm). Sympathetic tone was also lower in the trained group. Moreover, sympathetic tone was positively correlated with resting HR (r=0.7, P<0.05). The additional arterial pressure increase in hypertensive rats caused by ovarian hormone deprivation was attenuated by moderate-intensity dynamic resistance training. This benefit may be associated with resting bradycardia and reduced cardiac sympathetic tone after training, which suggests potential benefits of resistance exercise for the management of hypertension after ovarian hormone deprivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.