ArticleThe EMBO journal1989
Proenkephalin A is expressed in mesodermal lineages during organogenesis.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 74 citations in OpenAlex.
- Non-Coding SNPs Regulate Bovine Muscle Satellite Cell Proliferation and Differentiation by ModulatingInternational journal of molecular sciences · 2026Article
- Disparate Effects of Stressors on Met-Enkephalin System Parameters and on Plasma Concentrations of Corticosterone in Young Female Chickens.Animals : an open access journal from MDPI · 2024Article
- Pre-proenkephalin 1 is Downregulated Under Unloading and is Involved in Osteoblast Biology.Calcified tissue international · 2024Article
- Review
- Localization ofThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens.Scientific reports · 2019Article
- Elevated proenkephalin-derived peptide levels in ACTH-producing adenomas: nucleus and cytoplasm localization.Endocrine · 1998Article
- Regulation of the expression of the proenkephalin gene in cultured meningeal fibroblasts: opposite effects of alpha 1- and beta 2-adrenoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Proenkephalin is a nuclear protein responsive to growth arrest and differentiation signals.The Journal of cell biology · 1995Article
- Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element.Molecular and cellular biology · 1994Article
- Expression of prepro-enkephalin in human articular chondrocytes is linked to cell proliferation.The EMBO journal · 1992Article
- Proenkephalin A in bone-derived cells.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in vivo.The Journal of clinical investigation · 1990Article
- The testis-specific transcript (ferT) of the tyrosine kinase FER is expressed during spermatogenesis in a stage-specific manner.Molecular and cellular biology · 1990Article
- Regulated expression of proenkephalin A during ontogenic development of mesenchymal derivative tissues.Molecular and cellular biology · 1990Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proenkephalin A (PEA) encodes several neuropeptides with an opioid activity, as well as other peptides with as yet unknown functions. As an initial step toward finding possible roles for PEA gene products in non-neuronal tissues, we have determined sites of PEA expression during mouse embryonic development, employing in situ hybridization. We report here the unexpected observation that in addition to its abundance in brain, PEA RNA is expressed in non-differentiated mesodermal cells of diverse lineages in the process of their development into several adult tissues and organs; it drops to undetectable levels upon terminal differentiation of these tissues. In a particular example of differentiating mesoderm, the developing kidney, the transient expression of PEA mRNA and of its encoded peptide Met-enkephalin was demonstrated by both in situ and Northern blot hybridizations, as well as by a radioimmunoassay. These findings suggest a novel role for PEA-derived peptide(s) in mesoderm growth or differentiation during organogenesis.
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