ArticleKidney international2015
Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery.
Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Heart-Type Fatty Acid-Binding Protein as a Marker of Subclinical Cardiac Dysfunction and Cardiorenal Interaction in Autosomal Dominant Polycystic Kidney Disease.Life (Basel, Switzerland) · 2026Article
- Review
- Fatty acid-binding protein-3 and renal function decline in patients with chronic coronary syndrome.Clinical cardiology · 2024Article
- Urinary Biomarkers in a Living Donor Kidney Transplantation Cohort-Predictive Value on Graft Function.International journal of molecular sciences · 2023Article
- Machine learning in the prediction of cardiac surgery associated acute kidney injury with early postoperative biomarkers.Frontiers in surgery · 2023Article
- Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients.Translational research : the journal of laboratory and clinical medicine · 2021Article
- Urinary Spermidine Predicts and Associates with In-Hospital Acute Kidney Injury after Cardiac Surgery.Antioxidants (Basel, Switzerland) · 2021Article
- Using the SYNTAX score to predict myocardial injury early after on-pump coronary artery bypass surgery: a single-centre experience analysis.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2020Article
- Developing Biomarker Panels to Predict Progression of Acute Kidney Injury After Cardiac Surgery.Kidney international reports · 2019Article
- Stratifying risk of acute kidney injury in pre and post cardiac surgery patients using a novel biomarker-based algorithm and clinical risk score.Scientific reports · 2019Article
- Acute Kidney Injury after Cardiac Surgery: Risk Factors and Novel Biomarkers.Brazilian journal of cardiovascular surgery · 2019Review
- Biomarkers of Acute Kidney Injury after Cardiac Surgery: A Narrative Review.BioMed research international · 2019Review
- Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study.Biomarker research · 2018Article
- Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery.Biomarkers in medicine · 2017Article
- Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery.Journal of the American Society of Nephrology : JASN · 2017Article
- A comprehensive analysis and annotation of human normal urinary proteome.Scientific reports · 2017Article
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12 authors at 5 institutions in 2 countries.
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Abstract
Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Since heart fatty acid binding protein (H-FABP) is a myocardial protein that detects cardiac injury, we sought to determine whether plasma H-FABP was associated with AKI in the TRIBE-AKI cohort; a multi-center cohort of 1219 patients at high risk for AKI who underwent cardiac surgery. The primary outcomes of interest were any AKI (Acute Kidney Injury Network (AKIN) stage 1 or higher) and severe AKI (AKIN stage 2 or higher). The secondary outcome was long-term mortality after discharge. Patients who developed AKI had higher levels of H-FABP pre- and postoperatively than patients who did not have AKI. In analyses adjusted for known AKI risk factors, first postoperative log(H-FABP) was associated with severe AKI (adjusted odds ratio (OR) 5.39 (95% confidence interval (CI), 2.87-10.11) per unit increase), while preoperative log(H-FABP) was associated with any AKI (2.07 (1.48-2.89)) and mortality (1.67 (1.17-2.37)). These relationships persisted after adjustment for change in serum creatinine (for first postoperative log(H-FABP)) and biomarkers of cardiac and kidney injury, including brain natriuretic peptide, cardiac troponin-I, interleukin-18, liver fatty acid binding protein, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin. Thus, perioperative plasma H-FABP levels may be used for risk stratification of AKI and mortality following cardiac surgery.
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