Evidence map›Paper›PMID 25830558›Full record

ArticleAnnals of gastroenterology

The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.

Marilia Carabotti, Annunziata Scirocco, Maria Antonietta Maselli, Carola Severi

Erratum issued 3 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 1,599 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,599citing papers in PubMed, 16 pooled it
68.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06205446 nacompletednot on this map

Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain Interaction: Impact on Gastrointestinal and Psychological Symptoms as Well as Autonomic Nervous System

TypeinterventionalSponsorBuddhist Tzu Chi General HospitalRan2023 to 2024Enrolled125ConditionsIrritable Bowel Syndrome, Healthy Subjects, Functional Gastrointestinal Disorders, Laryngopharyngeal RefluxArmsHealthy subjects : abdominal breathing, Laryngopharyngeal reflux disease subjects : abdominal breathing, Dyspepsia subjects : abdominal breathing, Irritable bowel disorder : abdominal breathing
NCT06279858 naunknown statusnot on this map

Probiotic Intervention for Microbiome Modifications and Consequential Clinical Improvements in Children With Fragile X Syndrome: Pilot Study

TypeinterventionalSponsorSpecila hospital for cerebral palsy and developmental neurologyRan2024 to 2024Enrolled15ConditionsFragile X SyndromeArmsProbiotics
NCT06755489 nacompletednot on this map

Evaluation of Quality of Life in a Cohort of Diarrhoeic Irritable Bowel Syndrome (IBS-D) Patients Assuming GABA.

TypeinterventionalSponsorUniversity of PisaRan2023 to 2025Enrolled20ConditionsDiarrhoea Predominant Irritable Bowel SyndromeArmsPlacebo, GABA
3 · Its place in the literature

Who cites it

1,599 citing papers in PubMed, 16 syntheses or guidelines pooled it, 2,588 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?Comprehensive reviews in food science and food safety · 2026
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Trial
  18. Frontiers in nutrition · 2026
    Trial
  19. Review
  20. Gut microbes · 2026
    Article

1,539 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marilia CarabottiDepartment of Internal Medicine and Medical Specialties, University Sapienza, Rome (Marilia Carabotti, Annunziata Scirocco, Carola Severi), Italy.
Annunziata SciroccoDepartment of Internal Medicine and Medical Specialties, University Sapienza, Rome (Marilia Carabotti, Annunziata Scirocco, Carola Severi), Italy.
Maria Antonietta MaselliExperimental Pharmacology Laboratory, Scientific Institute of Gastroenterology S. de Bellis, Castellana Grotte, Bari (Maria Antonietta Maselli), Italy.
Carola SeveriDepartment of Internal Medicine and Medical Specialties, University Sapienza, Rome (Marilia Carabotti, Annunziata Scirocco, Carola Severi), Italy.
Ospedale SS. Annunziata · ITGastroenterology Hospital "Saverio de Bellis" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut-brain axis (GBA) consists of bidirectional communication between the central and the enteric nervous system, linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent advances in research have described the importance of gut microbiota in influencing these interactions. This interaction between microbiota and GBA appears to be bidirectional, namely through signaling from gut-microbiota to brain and from brain to gut-microbiota by means of neural, endocrine, immune, and humoral links. In this review we summarize the available evidence supporting the existence of these interactions, as well as the possible pathophysiological mechanisms involved. Most of the data have been acquired using technical strategies consisting in germ-free animal models, probiotics, antibiotics, and infection studies. In clinical practice, evidence of microbiota-GBA interactions comes from the association of dysbiosis with central nervous disorders (i.e. autism, anxiety-depressive behaviors) and functional gastrointestinal disorders. In particular, irritable bowel syndrome can be considered an example of the disruption of these complex relationships, and a better understanding of these alterations might provide new targeted therapies.

Indexed as

central nervous systementeric microbiotaenteric nervous systemGut-brain axisirritable bowel syndrome

Identifiers

PMID25830558
PMCPMC4367209
OpenAlexW1663623302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.