Evidence map›Paper›PMID 25830521›Full record

ArticleAmerican journal of respiratory and critical care medicine2015

Endothelial chromosome 13 deletion in congenital heart disease-associated pulmonary arterial hypertension dysregulates SMAD9 signaling.

Kylie M Drake, Suzy A Comhair, Serpil C Erzurum, Rubin M Tuder, Micheala A Aldred

Abstract readCase ReportsLetter
In one paragraph

Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Observational
  2. Review
  3. Review
  4. The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology.International journal of molecular sciences · 2021
    Review
  5. Review
  6. Review
  7. Article
  8. Genetics and genomics of pulmonary arterial hypertension.The European respiratory journal · 2019
    Review
  9. ALK1 signaling in development and disease: new paradigms.Cellular and molecular life sciences : CMLS · 2017
    Review
  10. Genetics of Pulmonary Arterial Hypertension.Seminars in respiratory and critical care medicine · 2017
    Review
  11. Review
  12. Endothelial Cell Reactive Oxygen Species and CaAdvances in experimental medicine and biology · 2017
    Review
  13. Article
  14. Article
  15. Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2015
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kylie M Drake1 Cleveland Clinic Cleveland, Ohio.
Suzy A Comhair
Serpil C Erzurum
Rubin M Tuder
Micheala A Aldred

Funding

Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
NITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Nitric Oxide in Pulmonary HypertensionR37HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2009 to 2018
$3.9M
Germline and Somatic Genetic Changes in Pulmonary Arterial HypertensionR01HL098199 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ALDRED, MICHEALA A · 2010 to 2017
$2.3M
Role of the X-chromosome in Pulmonary Arterial HypertensionR03HL110831 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ALDRED, MICHEALA A · 2011 to 2012
$157k
NHLBI NIH HHS R01 HL098199NHLBI NIH HHS R01HL098199NHLBI NIH HHS R03 HL110831NHLBI NIH HHS R03HL110831NHLBI NIH HHS R24 HL123767NHLBI NIH HHS R37 HL060917NHLBI NIH HHS RC37HL60917NHLBI NIH HHS U10 HL109250
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chromosome DeletionAdolescentAdultChromosomes, Human, Pair 13EndotheliumFemaleGenetic Predisposition to DiseaseHeart Defects, CongenitalHumansHypertension, PulmonarySignal TransductionSmad8 ProteinYoung AdultSmad8 Protein

Identifiers

PMID25830521
PMCPMC4407488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.