ArticleInternational journal of molecular sciences2015
A double-edged sword: the role of VEGF in wound repair and chemoattraction of opportunist pathogens.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Vascular Endothelial Growth Factor a Promotes Chronic Itch via VEGFA-VEGFR2-PI3K-TRPV1 Axis in Allergic Contact Dermatitis.Journal of inflammation research · 2024Article
- Wound healing effects of Asparagus lucidus Lindl extract through the phosphorylation of ERK1/2.BMC complementary medicine and therapies · 2023Article
- Article
- Anti-VEGFR therapy is one of the healing inhibitors of antiresorptive-related osteonecrosis of the jaw.Journal of bone and mineral metabolism · 2021Article
- The immunologic changes during different phases of intestinal anastomotic healing.Journal of clinical laboratory analysis · 2020Review
- Does survivin overexpression enhance the efficiency of fibroblast cell-based wound therapy?Molecular biology reports · 2020Article
- Insights into Host-Pathogen Interactions in Biofilm-Infected Wounds Reveal Possibilities for New Treatment Strategies.Antibiotics (Basel, Switzerland) · 2020Review
- Overexpression of cathepsin K and vascular endothelial growth factor in chronic venous ulcerations.Postepy dermatologii i alergologii · 2020Article
- Review
- Visfatin Promotes Wound Healing through the Activation of ERK1/2 and JNK1/2 Pathway.International journal of molecular sciences · 2018Article
- Pseudomonas aeruginosa biofilm hampers murine central wound healing by suppression of vascular epithelial growth factor.International wound journal · 2018Article
- Hydrogel and Platelet-Rich Plasma Combined Treatment to Accelerate Wound Healing in a Nude Mouse Model.Archives of plastic surgery · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is a complex process essential to repairing damaged tissues and preventing infection. Skin is the first line of defense, a chief physical barrier to microbe entry. Wound healing is a physical rebuilding process, but at the same time it is an inflammatory event. In turn, molecules for wound repair are secreted by fibroblasts and others present at the wound site. Vascular endothelial growth factor (VEGF) is a critical cytokine that exhibits chemoattractant properties, recruiting other immune cells to the site. Although generally beneficial, VEGF may also act as a chemoattractant for invading microorganisms, such as Pseudomonas aeruginosa. P. aeruginosa is problematic during wound infection due to its propensity to form biofilms and exhibit heightened antimicrobial resistance. Here, we explored the influence of VEGF gradients (in a microfluidic device wound model) on the motility and chemotactic properties of P. aeruginosa. At lower concentrations, VEGF had little effect on motility, but as the maximal concentration within the gradient increased, P. aeruginosa cells exhibited directed movement along the gradient. Our data provide evidence that while beneficial, VEGF, in excess, may aid colonization by P. aeruginosa. This highlights the necessity for the efficient resolution of inflammation. Understanding the dynamics of wound colonization may lead to new/enhanced therapeutics to hasten recovery.
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