Trial reportThe Journal of clinical psychiatry2015
The RAISE early treatment program for first-episode psychosis: background, rationale, and study design.
Trial report in The Journal of clinical psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 76 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recovery After an Initial Schizophrenia Episode (RAISE): RAISE Early Treatment Program
Enhancing Evidence-Based Practice for Youth and Emerging Adults With Early Psychosis: Implementation and Evaluation in Diverse Service Settings
Who cites it
76 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Specialised early intervention teams (extended time) for recent-onset psychosis.The Cochrane database of systematic reviews · 2020Pooled it
- Specialised early intervention teams for recent-onset psychosis.The Cochrane database of systematic reviews · 2020Pooled it
- Interventions for obtaining and maintaining employment in adults with severe mental illness, a network meta-analysis.The Cochrane database of systematic reviews · 2017Pooled it
- Autonomy Support from Healthcare Professionals Improves Functioning in Early Psychosis Through Psychological Growth.Schizophrenia bulletin · 2026Trial
- Race/ethnicity and socioeconomic status as predictors of outcome following family therapy in youth at clinical high risk for psychosis.Early intervention in psychiatry · 2024Trial
- The impact of early intervention for first episode psychosis on cognitive functioning.Schizophrenia research · 2023Trial
- Relationship between patterns of cannabis use and functional and symptomatic trajectories in first-episode psychosis.European archives of psychiatry and clinical neuroscience · 2023Trial
- A Randomized Controlled Trial of the Effects of Early Intervention Services On Insight in First Episode Psychosis.Schizophrenia bulletin · 2022Trial
- Exercise Intervention in Individuals at Clinical High Risk for Psychosis: Benefits to Fitness, Symptoms, Hippocampal Volumes, and Functional Connectivity.Schizophrenia bulletin · 2022Trial
- Outcomes During and After Early Intervention Services for First-Episode Psychosis: Results Over 5 Years From the RAISE-ETP Site-Randomized Trial.Schizophrenia bulletin · 2022Trial
- Socioeconomic status and the effectiveness of treatment for first-episode psychosis.Health services research · 2021Trial
- Predictors of Hospitalization of Individuals With First-Episode Psychosis: Data From a 2-Year Follow-Up of the RAISE-ETP.Psychiatric services (Washington, D.C.) · 2019Trial
- Implementation and fidelity assessment of the NAVIGATE treatment program for first episode psychosis in a multi-site study.Schizophrenia research · 2019Trial
- Racial-Ethnic Disparities in First-Episode Psychosis Treatment Outcomes From the RAISE-ETP Study.Psychiatric services (Washington, D.C.) · 2018Trial
- Prospective Relationships Between Motivation and Functioning in Recovery After a First Episode of Schizophrenia.Schizophrenia bulletin · 2018Trial
- Psychopharmacological Treatment in the RAISE-ETP Study: Outcomes of a Manual and Computer Decision Support System Based Intervention.The American journal of psychiatry · 2018Trial
- Paliperidone Palmitate Once-Monthly Treatment in Recent Onset and Chronic Illness Patients With Schizoaffective Disorder.The Journal of nervous and mental disease · 2017Trial
- Cost-Effectiveness of Comprehensive, Integrated Care for First Episode Psychosis in the NIMH RAISE Early Treatment Program.Schizophrenia bulletin · 2016Trial
- Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment Program.The American journal of psychiatry · 2016Trial
- Early psychosis research at Orygen, The National Centre of Excellence in Youth Mental Health.Social psychiatry and psychiatric epidemiology · 2016Trial
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveThe premise of the National Institute of Mental Health Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP) is to combine state-of-the-art pharmacologic and psychosocial treatments delivered by a well-trained, multidisciplinary team in order to significantly improve the functional outcome and quality of life for first-episode psychosis patients. The study is being conducted in non-academic (ie, real-world) treatment settings, using primarily extant reimbursement mechanisms.
methodWe developed a treatment model and training program based on extensive literature review and expert consultation. Our primary aim is to compare the experimental intervention to "usual care" on quality of life. Secondary aims include comparisons on remission, recovery, and cost-effectiveness. Patients 15-40 years old with a first episode of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychotic disorder not otherwise specified, or brief psychotic disorder according to DSM-IV and no more than 6 months of treatment with antipsychotic medications were eligible. Patients are followed for a minimum of 2 years, with major assessments conducted by blinded, centralized raters using live, 2-way video. We selected 34 clinical sites in 21 states and utilized cluster randomization to assign 17 sites to the experimental treatment and 17 to usual care. Enrollment began in July 2010 and ended in July 2012 with 404 subjects. The results of the trial will be published separately. The goal of the article is to present both the overall development of the intervention and the design of the clinical trial to evaluate its effectiveness.
conclusionsWe believe that we have succeeded in both designing a multimodal treatment intervention that can be delivered in real-world clinical settings and implementing a controlled clinical trial that can provide the necessary outcome data to determine its impact on the trajectory of early phase schizophrenia.
trial registrationClinicalTrials.gov identifier: NCT01321177.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.