ArticlePloS one2015
Experience-related structural changes of degenerated occipital white matter in late-blind humans - a diffusion tensor imaging study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Central visual pathways affected by degenerative retinal disease before and after gene therapy.Brain : a journal of neurology · 2024Article
- Reorganization of thalamocortical connections in congenitally blind humans.Human brain mapping · 2023Article
- Association Between Vision and Brain Cortical Thickness in a Community-Dwelling Elderly Cohort.Eye and brain · 2022Article
- The Effect of Congenital and Acquired Bilateral Anophthalmia on Brain Structure.Neuro-ophthalmology (Aeolus Press) · 2021Article
- Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract-based spatial statistics study.Brain and behavior · 2020Article
- Differences in the major fiber-tracts of people with congenital and acquired blindness.IS&T International Symposium on Electronic Imaging · 2020Article
- Overlapping Anatomical Networks Convey Cross-Modal Suppression in the Sighted and Coactivation of "Visual" and Auditory Cortex in the Blind.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- The development of white matter structural changes during the process of deterioration of the visual field.Scientific reports · 2019Article
- Article
- Altered functional connectivity of primary visual cortex in late blindness.Neuropsychiatric disease and treatment · 2018Article
- The visual white matter: The application of diffusion MRI and fiber tractography to vision science.Journal of vision · 2017Review
- Low Vision and Plasticity: Implications for Rehabilitation.Annual review of vision science · 2016Review
- Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans.Neural regeneration research · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-blind humans can learn to understand speech at ultra-fast syllable rates (ca. 20 syllables/s), a capability associated with hemodynamic activation of the central-visual system. Thus, the observed functional cross-modal recruitment of occipital cortex might facilitate ultra-fast speech processing in these individuals. To further elucidate the structural prerequisites of this skill, diffusion tensor imaging (DTI) was conducted in late-blind subjects differing in their capability of understanding ultra-fast speech. Fractional anisotropy (FA) was determined as a quantitative measure of the directionality of water diffusion, indicating fiber tract characteristics that might be influenced by blindness as well as the acquired perceptual skills. Analysis of the diffusion images revealed reduced FA in late-blind individuals relative to sighted controls at the level of the optic radiations at either side and the right-hemisphere dorsal thalamus (pulvinar). Moreover, late-blind subjects showed significant positive correlations between FA and the capacity of ultra-fast speech comprehension within right-hemisphere optic radiation and thalamus. Thus, experience-related structural alterations occurred in late-blind individuals within visual pathways that, presumably, are linked to higher order frontal language areas.
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