ArticleMedicine and science in sports and exercise2015
MRS Evidence of Adequate O₂ Supply in Human Skeletal Muscle at the Onset of Exercise.
Article in Medicine and science in sports and exercise, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Compromised muscle energetics and intracellular O2 availability during dynamic contraction in the plantar flexor muscles of patients with systemic sclerosis.Clinical science (London, England : 1979) · 2026Article
- In vivo quantification of mitochondrial OThe Journal of physiology · 2026Article
- Orosomucoid: a promising biomarker for the assessment of exercise-induced fatigue triggered by basic combat training.BMC sports science, medicine & rehabilitation · 2022Article
- A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise.European journal of applied physiology · 2022Review
- No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants.European journal of applied physiology · 2022Article
- Acute high-intensity exercise and skeletal muscle mitochondrial respiratory function: role of metabolic perturbation.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Transcapillary POThe Journal of physiology · 2020Article
- Skeletal muscle interstitial PoJournal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Central and peripheral factors mechanistically linked to exercise intolerance in heart failure with reduced ejection fraction.American journal of physiology. Heart and circulatory physiology · 2019Article
- Monitoring Exercise-Induced Muscle Fatigue and Adaptations: Making Sense of Popular or Emerging Indices and Biomarkers.Sports (Basel, Switzerland) · 2018Review
- Impact of 60 days of 6° head down tilt bed rest on muscular oxygen uptake and heart rate kinetics: efficacy of a reactive sledge jump countermeasure.European journal of applied physiology · 2018Article
- Mechanisms underlying extremely fast muscle V˙OPhysiological reports · 2018Article
- A mitochondrial-targeted antioxidant improves myofilament CaThe Journal of physiology · 2018Article
- Dissociating external power from intramuscular exercise intensity during intermittent bilateral knee-extension in humans.The Journal of physiology · 2017Article
- Muscle oxygenation during dynamic plantar flexion exercise: combining BOLD MRI with traditional physiological measurements.Physiological reports · 2016Article
- Response.Medicine and science in sports and exercise · 2015Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeAt exercise onset, intramuscular oxidative energy production responds relatively slowly in comparison with the change in adenosine triphosphate demand. To determine whether the slow kinetics of oxidative adenosine triphosphate production is due to inadequate O2 supply or metabolic inertia, we studied the kinetics of intramyocellular deoxygenation (deoxy-myoglobin (Mb)) and metabolism (phosphocreatine (PCr)) using proton (1H) and phosphorus (31P) magnetic resonance spectroscopy in six healthy subjects (33 ± 5 yr).
methodsSpecifically, using dynamic plantarflexion exercise, rest to exercise and recovery were assessed at both 60% of maximum work rate (moderate intensity) and 80% of maximum work rate (heavy intensity).
resultsAt exercise onset, [PCr] fell without delay and with a similar time constant (τ) at both exercise intensities (approximately 33 s). In contrast, the increase in deoxy-Mb was delayed at exercise onset by 5-7 s, after which it increased with kinetics (moderate τ = 37 ± 9 s; heavy τ = 29 ± 6 s) that was not different from τPCr (P > 0.05). At cessation, deoxy-Mb recovered without time delay and more rapidly (τ = ∼20 s) than PCr (τ = ∼33 s) (P < 0.05).
conclusionsUsing a unique combination of in vivo magnetic resonance spectroscopy techniques with high time resolution, this study revealed a delay in intramuscular deoxygenation at the onset of exercise and rapid reoxygenation kinetics upon cessation. Together, these data imply that intramuscular substrate-enzyme interactions, and not O2 availability, determine the exercise onset kinetics of oxidative metabolism in healthy human skeletal muscles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.