ArticlePLoS genetics2015
Co-chaperone p23 regulates C. elegans Lifespan in Response to Temperature.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- TheiScience · 2025Article
- Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans.Nature communications · 2024Article
- Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B.Scientific reports · 2024Article
- Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes.Nature aging · 2023Article
- The longevity response to warm temperature is neurally controlled via the regulation of collagen genes.Aging cell · 2023Article
- Organismal Roles of Hsp90.Biomolecules · 2023Review
- Temperature-Dependent Regulation of Proteostasis and Longevity.Frontiers in aging · 2022Review
- NScience advances · 2021Article
- Starvation Responses Throughout theGenetics · 2020Review
- Dietary restriction induces posttranscriptional regulation of longevity genes.Life science alliance · 2019Article
- MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis.PLoS biology · 2019Article
- Prostaglandin signals from adult germ stem cells delay somatic aging ofNature metabolism · 2019Article
- Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy.Nature communications · 2019Article
- When males outlive females: Sex-specific effects of temperature on lifespan in a cyclic parthenogen.Ecology and evolution · 2018Article
- Duplication of hsp-110 Is Implicated in Differential Success of Globodera Species under Climate Change.Molecular biology and evolution · 2018Article
- Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons.GeroScience · 2018Article
- Genetic interaction with temperature is an important determinant of nematode longevity.Aging cell · 2017Article
- The 4E-BP growth pathway regulates the effect of ambient temperature onProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity.Aging cell · 2017Article
- A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.PLoS genetics · 2016Article
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Temperature potently modulates various physiologic processes including organismal motility, growth rate, reproduction, and ageing. In ectotherms, longevity varies inversely with temperature, with animals living shorter at higher temperatures. Thermal effects on lifespan and other processes are ascribed to passive changes in metabolic rate, but recent evidence also suggests a regulated process. Here, we demonstrate that in response to temperature, daf-41/ZC395.10, the C. elegans homolog of p23 co-chaperone/prostaglandin E synthase-3, governs entry into the long-lived dauer diapause and regulates adult lifespan. daf-41 deletion triggers constitutive entry into the dauer diapause at elevated temperature dependent on neurosensory machinery (daf-10/IFT122), insulin/IGF-1 signaling (daf-16/FOXO), and steroidal signaling (daf-12/FXR). Surprisingly, daf-41 mutation alters the longevity response to temperature, living longer than wild-type at 25°C but shorter than wild-type at 15°C. Longevity phenotypes at 25°C work through daf-16/FOXO and heat shock factor hsf-1, while short lived phenotypes converge on daf-16/FOXO and depend on the daf-12/FXR steroid receptor. Correlatively daf-41 affected expression of DAF-16 and HSF-1 target genes at high temperature, and nuclear extracts from daf-41 animals showed increased occupancy of the heat shock response element. Our studies suggest that daf-41/p23 modulates key transcriptional changes in longevity pathways in response to temperature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.