Evidence map›Paper›PMID 25830118›Full record

ArticleAnesthesiology and pain medicine2015

Premedication with oral pregabalin for the prevention of acute postsurgical pain in coronary artery bypass surgery.

Mohsen Ziyaeifard, Mohammad Javad Mehrabanian, Seyedeh Zahra Faritus, Mehrdad Khazaei Koohpar, Rasool Ferasatkish, Heidar Hosseinnejad, Mohammadreza Mehrabanian

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesiology and pain medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04517110 phase3terminatednot on this mapstarted 2021, after this paper: background citation

Peri-Operative Pregabalin for Reducing opIoid Consumption AfTer Cardiac surgEry: A Randomized Trial

TypeinterventionalSponsorHamilton Health Sciences CorporationRan2021 to 2022Enrolled17ConditionsOpioid UseArmsPregabalin 300 mg, Pregabalin 75 mg, Pregabalin 300 mg Placebo, Pregabalin 75 mg Placebo, Usual Care
NCT06187922 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Perioperative Oral Pregabalin in Total Knee Replacement for Postoperative Pain

TypeinterventionalSponsorBahrain Defence Force HospitalRan2023 to 2025Enrolled120ConditionsPostoperative PainArmsPregabalin 75mg, adductor canal block
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery.Anesthesiology research and practice · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mohsen ZiyaeifardDepartment of Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, Iran.
Mohammad Javad MehrabanianDepartment of Cardiac Anesthesia, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran.
Seyedeh Zahra FaritusDepartment of Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, Iran.
Mehrdad Khazaei KoohparDepartment of Cardiac Anesthesia, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran.
Rasool FerasatkishDepartment of Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, Iran.
Heidar HosseinnejadDepartment of Anesthesia, Shahrood Branch of Islamic Azad University, Shahrood, Iran.
Mohammadreza MehrabanianDepartment of Neurosurgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shaheed Rajaei Cardiovascular Medical and Research Center · IRShahid Sadoughi University of Medical Sciences and Health Services · IRIslamic Azad University, Shahrood · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFor coronary artery bypass grafting (CABG) sternotomy should be performed. The pain after surgery is severe and requires medical intervention. Use of the analgesics is limited by their side effects and studies suggest that prevention with some medications before surgery is effective in controlling the postoperative pain.

objectivesWe investigated the efficacy of pregabalin administration before surgery in the treatment of acute postoperative pain after CABG surgery. PATIENTS AND

methodsSixty patients indicated for elective CABG surgery were randomly allocated to two groups. One group received placebo and the other received 150 mg of oral pregabalin before surgery. Heart rates, blood pressure, respiratory rate, intensive care unit (ICU) stay duration, morphine consumption, and pain score according to the visual analog scale (VAS) were measured and recorded at 4, 12, and 24 hours of surgery.

resultsPregabalin consumption did not alter hemodynamic parameters and was safe in patients after CABG. Its consumption was associated with significant reduction in the pain score (P values were 0.035, 0.026, and 0.047 respectively at 4, 12, and 24 hours of surgery). Its use was not associated with changes in the morphine consumption at 4, 12, and 24 hours of surgery (P > 0.05).

conclusionsPremedication with studied dose of pregabalin is effective for the prevention of postoperative pain in patients after CABG and has no adverse effects. Trials with other treating schedule and doses of the drug should be performed to determine the best treatment plan.

Indexed as

Acute PainCoronary Artery BypassMorphinePain ManagementPregabalin

Identifiers

PMID25830118
PMCPMC4363739
OpenAlexW2154037296

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.