ArticleSpringerPlus2015
Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond.
Article in SpringerPlus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 165 citations in OpenAlex.
- Enzyme-treated soybean meal in diets for weanling pigs: review.Animal bioscience · 2026Article
- Fine-tuning the lysine-arginine duet: a dietary approach to suppress tumor growth.Molecular biomedicine · 2026Article
- Reducing dietary crude protein for gestating and lactating sows reduces daily nitrogen retention, but reproductive performance is not impacted by diet protein concentration.Journal of animal science and biotechnology · 2026Article
- Combined Multi-Omics Analysis Reveals the Potential Role of Methionine in Regulating the Proliferation, Differentiation, and Lipid Deposition of Yak Intramuscular Preadipocytes.Animals : an open access journal from MDPI · 2026Article
- Demonstration of an integrated process for manure-based nitrogen recovery using the biopolymer cyanophycin.Journal of industrial microbiology & biotechnology · 2026Article
- Effect of high dietary lysine on growth performance and body composition in weaned pigs following a period with dietary protein restriction: a preliminary study.Journal of animal science · 2026Article
- Lysine-rich rice enhanced muscle growth and development in young rats.European journal of nutrition · 2025Article
- Statistical methodologies for enhancing lipase production from Aspergillus Niger and using biologically treated cottonseed waste in animal nutrition.Scientific reports · 2025Article
- Effect of Rumen-Protected Lysine Supplementation on Growth Performance, Blood Metabolites, Rumen Fermentation and Bacterial Community on Feedlot Yaks Offered Corn-Based Diets.Animals : an open access journal from MDPI · 2025Article
- Optimization of Solid Lipid Microcapsule Matrix for Enhanced Release and Bioavailability of L-Lysine in Swine.Animals : an open access journal from MDPI · 2025Article
- The Association Between Hematological Profiles and Whole-Blood Transcriptome Genes Identified Using Quantitative Analysis with Average Daily Gain and Feed Efficiency in Forage-Fed Beef Heifers.International journal of molecular sciences · 2025Article
- The Effect of Reduced Dietary Protein on Adipose Tissue in Local Krškopolje Pigs.International journal of molecular sciences · 2025Article
- Fermentation ofMolecules (Basel, Switzerland) · 2025Article
- Effects of Feeding Methionine Hydroxyl Analogue Chelated Zinc, Copper, and Manganese on Growth Performance, Nutrient Digestibility, Mineral Excretion and Welfare Conditions of Broiler Chickens: Part 1: Performance Aspects.Animals : an open access journal from MDPI · 2025Article
- Optimizing diets for finishing pigs: balancing ideal protein to enhance growth performance and reduce environmental impacts.Translational animal science · 2025Article
- Effects of rumen-protected lysine on antler growth performance, fecal bacterial community, and blood gene expression in sika deer.Frontiers in veterinary science · 2025Article
- Transcriptomic Analysis of the Hepatopancreas in the Sex-Related Size Differences ofVeterinary sciences · 2024Article
- Dietary Crude Protein and Lysine Levels Affect Meat Quality and Myofiber Characteristic of Slow-Growing Chicken.Animals : an open access journal from MDPI · 2024Article
- Regional Variability in Sugar and Amino Acid Content of U.S. Soybeans and the Impact of Autoclaving on Reducing Sugars and Free Lysine.Foods (Basel, Switzerland) · 2024Article
- Biomarkers for ideal protein: rabbit diet metabolomics varying key amino acids.Communications biology · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Improving feed efficiency of pigs with dietary application of amino acids (AAs) is becoming increasingly important because this practice can not only secure the plasma AA supply for muscle growth but also protect the environment from nitrogen discharge with feces and urine. Lysine, the first limiting AA in typical swine diets, is a substrate for generating body proteins, peptides, and non-peptide molecules, while excess lysine is catabolized as an energy source. From a regulatory standpoint, lysine is at the top level in controlling AA metabolism, and lysine can also affect the metabolism of other nutrients. The effect of lysine on hormone production and activities is reflected by the change of plasma concentrations of insulin and insulin-like growth factor 1. Lysine residues in peptides are important sites for protein post-translational modification involved in epigenetic regulation of gene expression. An inborn error of a cationic AA transporter in humans can lead to a lysinuric protein intolerance condition. Dietary deficiency of lysine will impair animal immunity and elevate animal susceptibility to infectious diseases. Because lysine deficiency has negative impact on animal health and growth performance and it appears that dietary lysine is non-toxic even at a high dose of supplementation, nutritional emphasis should be put on lysine supplementation to avoid its deficiency rather than toxicity. Improvement of muscle growth of monogastric animals such as pigs via dietary lysine supply may be due to a greater increase in protein synthesis rather than a decrease in protein degradation. Nevertheless, the underlying metabolic and molecular mechanisms regarding lysine effect on muscle protein accretion merits further clarification. Future research undertaken to fully elucidate the metabolic and regulatory mechanisms of lysine nutrition could provide a sound scientific foundation necessary for developing novel nutritional strategies to enhance the muscle growth and development of meat animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.