ArticleKorean journal of ophthalmology : KJO2015
Deep anterior lamellar keratoplasty using irradiated acellular cornea with amniotic membrane transplantation for intractable ocular surface diseases.
Article in Korean journal of ophthalmology : KJO, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Low-temperature vacuum evaporation as a novel dehydration process for the long-term preservation of transplantable human corneal tissue.Cell and tissue banking · 2025Article
- Preparation of Decellularized Amniotic Membrane and Adipose-Derived Stromal/Stem Cell Seeding.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Toward electron-beam sterilization of a pre-assembled Boston keratoprosthesis.The ocular surface · 2021Article
- Clinical Aspects of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Severe Ocular Complications in South Korea.Frontiers in medicine · 2021Review
- Large-diameter Deep Anterior Lamel-lar Keratoplasty: An Alternative Treatment for Mooren Ulcer.Korean journal of ophthalmology : KJO · 2020Article
- Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts.Acta biomaterialia · 2019Article
- Long-term clinical outcomes of keratoplasty using gamma-irradiated corneal lenticules.BMJ open ophthalmology · 2019Article
- Cross-linked decellularized porcine corneal graft for treating fungal keratitis.Scientific reports · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo report the clinical outcomes of deep anterior lamellar keratoplasty (DALK) when sterile gamma-irradiated acellular corneal tissues (VisionGraft) are used in combination with amniotic membrane transplantation (AMT) for intractable ocular surface diseases.
methodsThe medical records of fifteen patients who had DALK with AMT were retrospectively reviewed. Indications for surgery included ocular burn, bacterial keratitis, herpes simplex virus keratitis, corneal opacity with Stevens-Johnson syndrome, Mooren's ulcer, idiopathic myxoid degeneration of corneal stroma, and recurrent band keratopathy. DALK was performed using partial-thickness acellular corneal tissue and a temporary amniotic membrane patch was added at the end of the operation.
resultsAll cases that underwent DALK with AMT became epithelialized within 2 postoperative weeks. Twelve patients showed favorable outcomes without graft rejection, corneal opacification, or neovascularization. The other three grafts developed corneal opacification and neovascularization, and required additional penetrating keratoplasty (PK). Unlike the results of previous PKs, there were no graft rejections and the graft clarity was well-maintained in these three cases for at least 8 months after PK.
conclusionsDALK using sterile acellular corneal tissues in combination with AMT may be a good therapeutic strategy for treating intractable ocular surface diseases because of lowered immune rejection, fibroblast activation, and facilitation of epithelialization. Furthermore, DALK can help stabilize the ocular surface, prolong graft survival, and may allow better outcomes when combined with subsequent PK.
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