ArticleJournal of Korean medical science2015
Risk factors for late-onset hyponatremia and its influence on neonatal outcomes in preterm infants.
Article in Journal of Korean medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Higher versus lower sodium intake for preterm infants.The Cochrane database of systematic reviews · 2023Pooled it
- Effect of early sodium supplementation on weight gain of very preterm infants: a randomised controlled trial.BMJ paediatrics open · 2025Trial
- Maintenance intravenous fluid therapy in infants with sepsis and hyponatremia: a clinical trial.BMC pediatrics · 2024Trial
- Maternal low sodium intake and early postnatal diuretics program metabolic and ventilatory dysfunction in mice.Pediatric research · 2026Article
- The Changing Landscape of Sodium Needs in the Preterm Neonate for Optimizing Growth and Development.Nutrients · 2026Review
- Article
- The Effects of Diet, Dietary Supplements, Drugs and Exercise on Physical, Diagnostic Values of Urine Characteristics.Nutrients · 2024Review
- Case report: Acute severe hyponatremia-induced seizures in a newborn: a community-acquired case and literature review.Frontiers in pharmacology · 2024Article
- Sodium and Growth in Preterm Infants: A Review.Newborn (Clarksville, Md.) · 2023Article
- Article
- Hypochloremia Secondary to Diuretics in Preterm Infants: Should Clinicians Pay Close Attention?Global pediatric health · 2021Review
- Risk Factors and Effects of Severe Late-Onset Hyponatremia on Long-Term Growth of Prematurely Born Infants.Pediatric gastroenterology, hepatology & nutrition · 2020Article
- Dysnatremia in extremely low birth weight infants is associated with multiple adverse outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Maintenance Fluids for Late Preterm and Term Infants: Is it Time to Reconsider?Pediatrics open scienceArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-onset hyponatremia (LOH), hyponatremia occurring after two weeks of age with the achievement of full feeding, is the result of a negative sodium balance caused by inadequate salt intake or excessive salt loss due to immature renal or intestinal function in preterm infants. The aims of our study were to identify the risk factors for LOH and its influence on neonatal outcomes. This was a retrospective cohort analysis of 161 preterm infants born before 34 weeks of gestation between June 2009 and December 2010 at Seoul National University Hospital. LOH was defined as a sodium level ≤ 132 mEq/L or 133-135 mEq/L with oral sodium supplementation. LOH occurred in 49 (30.4%) of the studied infants. A lower gestational age, a shorter duration of parenteral nutrition, the presence of respiratory distress syndrome, the use of furosemide, and feeding with breast milk were significant risk factors for LOH. In terms of neonatal outcomes, the infants with LOH had longer hospital stays and higher risks of bronchopulmonary dysplasia and retinopathy of prematurity requiring surgery. LOH lasting at least 7 days significantly increased moderate to severe bronchopulmonary dysplasia, periventricular leukomalacia, and extra-uterine growth retardation. LOH is commonly observed in preterm infants; it may be a risk factor for bronchopulmonary dysplasia and retinopathy of prematurity or a marker of illness severity.
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