ReviewJournal of the American Medical Informatics Association : JAMIA2015
Recommendations to improve the usability of drug-drug interaction clinical decision support alerts.
Review in Journal of the American Medical Informatics Association : JAMIA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Information needs for making clinical recommendations about potential drug-drug interactions: a synthesis of literature review and interviews.BMC medical informatics and decision making · 2017Pooled it
- Association between e-alert implementation for detection of acute kidney injury and outcomes: a systematic review.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Pooled it
- Drug interaction databases in medical literature: transparency of ownership, funding, classification algorithms, level of documentation, and staff qualifications. A systematic review.European journal of clinical pharmacology · 2015Pooled it
- SafeRx: A Canonical Pharmaceutical Knowledge Integration Framework for Multimodal Medication Safety.Bioengineering (Basel, Switzerland) · 2026Article
- The Role of Explanations in AI-Generated Alerts: Qualitative Study of Clinical Views on Explainable AI in Predictive Tools.JMIR human factors · 2026Article
- Evaluation of community pharmacists' knowledge and real-world practices in drug interaction management: a cross-sectional study.Frontiers in medicine · 2026Article
- Assessing Medication CDS Usability: Pilot Results from 10 Outpatient Clinics.Applied clinical informatics · 2025Article
- The Elements of Style for Interruptive Electronic Health Record Alerts.Applied clinical informatics · 2025Article
- Navigating Drug-Drug Interactions in Multimorbid Patients: Utilizing Tools, Guidelines, and Clinical Implications.Current drug safety · 2025Article
- A comparison of five different drug-drug interaction checkers for selective serotonin reuptake inhibitors.Frontiers in pharmacology · 2025Article
- Evaluation of an electronic health record Drug Interaction Customization Editor (DICE).American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2024Article
- The Impact of Customized Screening Intervals on the Burden of Drug-Drug Interaction Alerts: An Interrupted Time Series Analysis.Journal of medical systems · 2024Article
- Leveraging explainable artificial intelligence to optimize clinical decision support.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- PillHarmonics: An Orchestrated Pharmacogenetics Medication Clinical Decision Support Service.Applied clinical informatics · 2024Article
- Factors Influencing Health Care Professionals' Perceptions of Frequent Drug-Drug Interaction Alerts.ACI open · 2024Article
- Drug-drug interactions with oral anticoagulants: information consistency assessment of three commonly used online drug interactions databases in Switzerland.Frontiers in pharmacology · 2024Article
- Clinician Response to Pharmacogenetic Clinical Decision Support Alerts.Clinical pharmacology and therapeutics · 2023Article
- Article
- Cognitive task analysis of clinicians' drug-drug interaction management during patient care and implications for alert design.BMJ open · 2023Article
- Barriers to Adoption of Tailored Drug-Drug Interaction Clinical Decision Support.Applied clinical informatics · 2023Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
objectiveTo establish preferred strategies for presenting drug-drug interaction (DDI) clinical decision support alerts. MATERIALS AND
methodsA DDI Clinical Decision Support Conference Series included a workgroup consisting of 24 clinical, usability, and informatics experts representing academia, health information technology (IT) vendors, healthcare organizations, and the Office of the National Coordinator for Health IT. Workgroup members met via web-based meetings 12 times from January 2013 to February 2014, and two in-person meetings to reach consensus on recommendations to improve decision support for DDIs. We addressed three key questions: (1) what, how, where, and when do we display DDI decision support? (2) should presentation of DDI decision support vary by clinicians? and (3) how should effectiveness of DDI decision support be measured?
resultsOur recommendations include the consistent use of terminology, visual cues, minimal text, formatting, content, and reporting standards to facilitate usability. All clinicians involved in the medication use process should be able to view DDI alerts and actions by other clinicians. Override rates are common but may not be a good measure of effectiveness. DISCUSSION: Seven core elements should be included with DDI decision support. DDI information should be presented to all clinicians. Finally, in their current form, override rates have limited capability to evaluate alert effectiveness.
conclusionDDI clinical decision support alerts need major improvements. We provide recommendations for healthcare organizations and IT vendors to improve the clinician interface of DDI alerts, with the aim of reducing alert fatigue and improving patient safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.