ArticleThe Plant cell2015
Natural variation in epigenetic pathways affects the specification of female gamete precursors in Arabidopsis.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- Review
- From the MMC Specification to Endosperm Cellularization in Arabidopsis: A Developmental-Handover Framework for Seed Initiation.Plants (Basel, Switzerland) · 2026Review
- MADS31 supports female germline development by repressing the post-fertilization programme in cereal ovules.Nature plants · 2025Article
- The DNA methylation-demethylation balance prevents development of multiple megaspore mother cells in Arabidopsis.The Plant cell · 2025Article
- The maternal embrace: the protection of plant embryos.Journal of experimental botany · 2024Review
- Germline β-1,3-glucan deposits are required for female gametogenesis in Arabidopsis thaliana.Nature communications · 2024Article
- The miRNA822 loaded by ARGONAUTE9 modulates the monosporic female gametogenesis in Arabidopsis thaliana.Plant reproduction · 2024Article
- Revisiting the female germline cell development.Frontiers in plant science · 2024Review
- Signaling by the EPFL-ERECTA family coordinates female germline specification through the BZR1 family in Arabidopsis.The Plant cell · 2023Article
- 3D cellular morphometrics of ovule primordium development inFrontiers in plant science · 2023Article
- Genomic methylation patterns in pre-meiotic gynoecia of wild-type and RdDM mutants of Arabidopsis.Frontiers in plant science · 2023Article
- Transcriptomic Analysis of Radish (Plants (Basel, Switzerland) · 2022Article
- Accumulation dynamics of ARGONAUTE proteins during meiosis in Arabidopsis.Plant reproduction · 2022Article
- Asymmetric expression of Argonautes in reproductive tissues.Plant physiology · 2022Article
- The emerging role of small RNAs in ovule development, a kind of magic.Plant reproduction · 2021Review
- High-throughput single-cell transcriptomics reveals the female germline differentiation trajectory in Arabidopsis thaliana.Communications biology · 2021Article
- Rice MutLγ, the MLH1-MLH3 heterodimer, participates in the formation of type I crossovers and regulation of embryo sac fertility.Plant biotechnology journal · 2021Article
- Article
- Epigenetic Regulation of Megaspore Mother Cell Formation.Frontiers in plant science · 2021Review
- H3.1 Eviction Marks Female Germline Precursors in Arabidopsis.Plants (Basel, Switzerland) · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In angiosperms, the transition to the female gametophytic phase relies on the specification of premeiotic gamete precursors from sporophytic cells in the ovule. In Arabidopsis thaliana, a single diploid cell is specified as the premeiotic female gamete precursor. Here, we show that ecotypes of Arabidopsis exhibit differences in megasporogenesis leading to phenotypes reminiscent of defects in dominant mutations that epigenetically affect the specification of female gamete precursors. Intraspecific hybridization and polyploidy exacerbate these defects, which segregate quantitatively in F2 populations derived from ecotypic hybrids, suggesting that multiple loci control cell specification at the onset of female meiosis. This variation in cell differentiation is influenced by the activity of ARGONAUTE9 (AGO9) and RNA-DEPENDENT RNA POLYMERASE6 (RDR6), two genes involved in epigenetic silencing that control the specification of female gamete precursors. The pattern of transcriptional regulation and localization of AGO9 varies among ecotypes, and abnormal gamete precursors in ovules defective for RDR6 share identity with ectopic gamete precursors found in selected ecotypes. Our results indicate that differences in the epigenetic control of cell specification lead to natural phenotypic variation during megasporogenesis. We propose that this mechanism could be implicated in the emergence and evolution of the reproductive alternatives that prevail in flowering plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.