ArticleRetina (Philadelphia, Pa.)2015
DIRECTIONAL OPTICAL COHERENCE TOMOGRAPHY PROVIDES ACCURATE OUTER NUCLEAR LAYER AND HENLE FIBER LAYER MEASUREMENTS.
Article in Retina (Philadelphia, Pa.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed.
- Impact of Prophylactic Ranibizumab to Prevent Neovascular Age-Related Macular Degeneration on Eyes With Intermediate Age-Related Macular Degeneration.Translational vision science & technology · 2023Trial
- Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging.Translational vision science & technology · 2026Article
- The A53T Parkinson's Disease Mouse Model Shows Abnormal Outer Retinal OCT Metabolic Biomarker Patterns.Investigative ophthalmology & visual science · 2026Article
- Henle Fibers Are Organized in Bundles Consistent Between Individuals and Conserved in Primates.Investigative ophthalmology & visual science · 2026Article
- Review
- A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies.bioRxiv : the preprint server for biology · 2026Article
- Macular Metabolism in Young and Older Adults: A Preliminary Optical Coherence Tomography Biomarker Study.Investigative ophthalmology & visual science · 2026Article
- Detailed Outer Retinal Assessment in Parkinson's Disease Using Directional OCT.Investigative ophthalmology & visual science · 2026Article
- Developing Clinically Implementable Approaches for Directional Optical Coherence Tomography.Translational vision science & technology · 2026Article
- Volumetric and En Face Hyper-Reflective Henle Fiber Layer in Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2026Article
- Assessing the Relationship between Foveal Cone Density, Outer Nuclear Layer Thickness and Foveal Morphology.Ophthalmology science · 2026Article
- Characterizing Long-Chain 3-Hydroxy-Acyl-CoA Dehydrogenase Deficiency (LCHADD) Chorioretinopathy Using OCT and OCTA.Investigative ophthalmology & visual science · 2025Article
- Peptide Lv Deficiency Adversely Impacts the Structural and Functional Integrity of the Neural Retina.Investigative ophthalmology & visual science · 2025Article
- Keeping an eye on Parkinson's disease: color vision and outer retinal thickness as simple and non-invasive biomarkers.Journal of neurology · 2025Review
- Stratification of the Extent of Visual Impairment Identifies Sex-Specific Degenerative Changes in Retinal Structure and Function during Aging.Journal of integrative neuroscience · 2025Article
- OCT5k: A dataset of multi-disease and multi-graded annotations for retinal layers.Scientific data · 2025Article
- New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.Translational vision science & technology · 2025Review
- Quantifying the influence of optical coherence tomography beam tilt in each retinal layer.PloS one · 2025Article
- Onset and Progression of Disease in Nonhuman Primates With PDE6C Cone Disorder.Investigative ophthalmology & visual science · 2024Article
- A Comparative Analysis of Models for AAV-Mediated Gene Therapy for Inherited Retinal Diseases.Cells · 2024Review
28 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
purposeThe outer nuclear layer (ONL) contains photoreceptor nuclei, and its thickness is an important biomarker for retinal degenerations. Accurate ONL thickness measurements are obscured in standard optical coherence tomography (OCT) images because of Henle fiber layer (HFL). Improved differentiation of the ONL and HFL boundary is made possible by using directional OCT, a method that purposefully varies the pupil entrance position of the OCT beam.
methodsFifty-seven normal eyes were imaged using multiple pupil entry positions with a commercial spectral domain OCT system. Cross-sectional image sets were registered to each other and segmented at the top of HFL, the border of HFL and the ONL and at the external limiting membrane. Thicknesses of the ONL and HFL were measured and analyzed.
resultsThe true ONL and HFL thicknesses varied substantially by eccentricity and between individuals. The true macular ONL thickness comprised an average of 54.6% of measurements that also included HFL. The ONL and HFL thicknesses at specific retinal eccentricities were poorly correlated.
conclusionAccurate ONL and HFL thickness measurements are made possible by the optical contrast of directional OCT. Distinguishing these individual layers can improve clinical trial endpoints and assessment of disease progression.
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