ArticleJournal of neurogastroenterology and motility2015
Visceral pain and gastrointestinal microbiome.
Article in Journal of neurogastroenterology and motility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Comparative efficacy of probiotic, prebiotic, and synbiotic interventions in children with functional abdominal pain disorders: a systematic review and network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Pooled it
- Cystic Fibrosis-Related Gut Dysbiosis: A Systematic Review.Digestive diseases and sciences · 2023Pooled it
- Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of Irritable Bowel Syndrome: A systematic review and meta-analysis.Sultan Qaboos University medical journal · 2020Pooled it
- The Effect of Multiprobiotics on Memory and Attention in Fibromyalgia: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2021Trial
- Paradigm Shift of Microbiota-gut-brain Axis During Aging: Potential Role of Probiotics to Improve Cognitive Decline.Probiotics and antimicrobial proteins · 2026Review
- Experience of Maltreatment Is Associated With Abdominal Pain Intensity and Health-Related Quality of Life in Children With Pain-Predominant Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Article
- Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy.Regional anesthesia and pain medicine · 2025Review
- Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Causal effect of gut microbiota on the risk of prostatitis: a two-sample Mendelian randomization study.International urology and nephrology · 2024Article
- Probiotics Show Promise as a Novel Natural Treatment for Neurological Disorders.Current pharmaceutical biotechnology · 2024Review
- A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits.Neuropharmacology · 2023Review
- The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review.Frontiers in physiology · 2022Review
- Neuro-Immune Modulation Effects of Sacral Nerve Stimulation for Visceral Hypersensitivity in Rats.Frontiers in neuroscience · 2021Article
- The Role of HAdvances in experimental medicine and biology · 2021Article
- Gut-Brain Axis: Possible Role of Gut Microbiota in Perioperative Neurocognitive Disorders.Frontiers in aging neuroscience · 2021Review
- Dysbiosis in intestinal microbiome linked to fecal blood determined by direct hybridization.3 Biotech · 2020Article
- Repeated Vaginal Exposures to the Common Cosmetic and Household Preservative Methylisothiazolinone Induce Persistent, Mast Cell-Dependent Genital Pain in ND4 Mice.International journal of molecular sciences · 2019Article
- Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model.Journal of microbiology (Seoul, Korea) · 2019Article
- Enteric Glia: A New Player in Abdominal Pain.Cellular and molecular gastroenterology and hepatology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A complex set of interactions between the microbiome, gut and brain modulate responses to visceral pain. These interactions occur at the level of the gastrointestinal mucosa, and via local neural, endocrine or immune activity; as well as by the pro-duction of factors transported through the circulatory system, like bacterial metabolites or hormones. Various psychological, in-fectious and other stressors can disrupt this harmonious relationship and alter both the microbiome and visceral pain responses. There are critical sensitive periods that can impact visceral pain responses in adulthood. In this review we provide a brief background of the intestinal microbiome and emerging concepts of the bidirectional interactions between the micro-biome, gut and brain. We also discuss recent work in animal models, and human clinical trials using prebiotics and probiotics that alter the microbiome with resultant alterations in visceral pain responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.