Evidence map›Paper›PMID 25829233›Full record

ArticleClinical immunology (Orlando, Fla.)2015

Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720.

Mai Fujiwara, Emily J Anstadt, Kamal M Khanna, Robert B Clark

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mai FujiwaraDepartment of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.
Emily J AnstadtDepartment of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.
Kamal M KhannaDepartment of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.
Robert B ClarkDepartment of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA; Department of Medicine, University of Connecticut Health Center, Farmington, CT 06032, USA. Electronic address: rclark@nso2.uchc.edu.
UConn Health · US

Funding

Visualizing the innate and adaptive immune response to Listeria monocytogenesR01AI097375 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KHANNA, KAMAL MOHAN · 2012 to 2016
$2.1M
CSR NIH HHS RG4070B7/2NIAID NIH HHS AI097375NIAID NIH HHS R01 AI097375
6 · The paper itself

Abstract

The variable response to therapy in multiple sclerosis (MS) suggests a need for personalized approaches based on individual genetic differences. GWAS have linked CBLB gene polymorphisms with MS and recent evidence demonstrated that these polymorphisms can be associated with abnormalities in T cell function and response to interferon-β therapy. Cbl-b is an E3 ubiquitin ligase that regulates T cell activation and Cbl-b-deficient (Cbl-b(-/-)) mice show T cell abnormalities described in MS patients. We now show that Cbl-b(-/-) T cells demonstrate significant lymph node trafficking abnormalities. We thus asked whether the MS-approved drug, FTY720, postulated to trap T cells in lymphoid tissues, is less effective in the context of Cbl-b dysfunction. We now report that FTY720 significantly inhibits EAE in Cbl-b(-/-) mice. Our results newly document a role for Cbl-b in T cell trafficking but suggest nevertheless that MS patients with Cbl-b abnormalities may still be excellent candidates for FTY720 treatment.

Indexed as

Adaptor Proteins, Signal TransducingAdoptive TransferAnimalsCell MovementEncephalomyelitis, Autoimmune, ExperimentalFingolimod HydrochlorideHomeodomain ProteinsImmunosuppressive AgentsLymph NodesLymphocyte ActivationMiceMice, KnockoutMultiple SclerosisPropylene GlycolsProto-Oncogene Proteins c-cblSphingosineAdaptor Proteins, Signal TransducingCblb protein, mouseFingolimod HydrochlorideHomeodomain ProteinsImmunosuppressive AgentsPropylene GlycolsProto-Oncogene Proteins c-cblRAG-1 proteinSphingosineCasitas-B lineage lymphoma-bExperimental autoimmune encephalomyelitisFTY720Multiple sclerosisSphingosine-1-phosphate receptor 1T cell trafficking

Identifiers

PMID25829233
PMCPMC4420730
OpenAlexW1991174663

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.