ArticlePlastic and reconstructive surgery2015
Studies in Fat Grafting: Part V. Cell-Assisted Lipotransfer to Enhance Fat Graft Retention Is Dose Dependent.
Article in Plastic and reconstructive surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Systematic review of the efficacy of fat grafting and platelet-rich plasma for wound healing.International wound journal · 2018Pooled it
- SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescenceBurns & trauma · 2026Article
- Exosome-Mediated Enhancement of Fat Graft Retention: A Comparative Preclinical Study with Stromal Vascular Fraction.Aesthetic plastic surgery · 2025Article
- Integrated Fluidic Platform for Washing and Mechanical Processing of Lipoaspirate for Downstream Fat Grafting and Regenerative Applications.Bioengineering (Basel, Switzerland) · 2025Article
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- The Effects of Platelet-Rich Plasma and Adipose-Derived Stem Cells on Neovascularization and Fat Graft Survival.Aesthetic plastic surgery · 2024Article
- Adipose stem cells regulate lipid metabolism by upregulating mitochondrial fatty acid β-oxidation in macrophages to improve the retention rate of transplanted fat.Stem cell research & therapy · 2024Article
- Soft Tissue Reconstruction.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Stem Cell Therapy Enriched Fat Grafting for the Reconstruction of Craniofacial Deficits.Plastic and reconstructive surgery. Global open · 2023Article
- Strategies to Improve AFT Volume Retention After Fat Grafting.Aesthetic plastic surgery · 2023Article
- Current Fat Grafting Practices and Preferences: A Survey from Members of ISPRES.Plastic and reconstructive surgery. Global open · 2023Article
- A Bibliometric and Visualization Analysis on the Research of Fat Grafting from 1945 to 2021.Aesthetic plastic surgery · 2023Review
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- Review
- Mechanical Stress Improves Fat Graft Survival by Promoting Adipose-Derived Stem Cells Proliferation.International journal of molecular sciences · 2022Article
- Fat Grafts Augmented With Vitamin E Improve Volume Retention and Radiation-Induced Fibrosis.Aesthetic surgery journal · 2022Article
- Fat Grafting: Basic Science, Techniques, and Patient Management.Plastic and reconstructive surgery. Global open · 2022Review
- Angiogenic CD34+CD146+ adipose-derived stromal cells augment recovery of soft tissue after radiotherapy.Journal of tissue engineering and regenerative medicine · 2021Article
- Effects of radiation and chemotherapy on adipose stem cells: Implications for use in fat grafting in cancer patients.World journal of stem cells · 2021Review
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCell-assisted lipotransfer has shown much promise as a technique for improving fat graft take. However, the concentration of stromal vascular fraction cells required to optimally enhance fat graft retention remains unknown.
methodsHuman lipoaspirate was processed for both fat transfer and harvest of stromal vascular fraction cells. Cells were then mixed back with fat at varying concentrations ranging from 10,000 to 10 million cells per 200 μl of fat. Fat graft volume retention was assessed by means of computed tomographic scanning over 8 weeks, and then fat grafts were explanted and compared histologically for overall architecture and vascularity.
resultsMaximum fat graft retention was seen at a concentration of 10,000 cells per 200 μl of fat. The addition of higher number of cells negatively impacted fat graft retention, with supplementation of 10 million cells producing the lowest final volumes, lower than fat alone. Interestingly, fat grafts supplemented with 10,000 cells showed significantly increased vascularity and decreased inflammation, whereas fat grafts supplemented with 10 million cells showed significant lipodegeneration compared with fat alone
conclusions: The authors' study demonstrates dose dependence in the number of stromal vascular fraction cells that can be added to a fat graft to enhance retention. Although cell-assisted lipotransfer may help promote graft survival, this effect may need to be balanced with the increased metabolic load of added cells that may compete with adipocytes for nutrients during the postgraft period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.