ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Transmission of Mycobacterium tuberculosis in China: a population-based molecular epidemiologic study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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57 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Molecular clustering of patients with diabetes and pulmonary tuberculosis: A systematic review and meta-analysis.PloS one · 2017Pooled it
- First Insight into the Molecular Epidemiology ofBioMed research international · 2017Trial
- A First Insight into the Genetic Diversity and Drug Susceptibility Pattern ofBioMed research international · 2016Trial
- Sputum-negative pulmonary tuberculosis in Shanghai, China: notification, clinical characteristics and outcomes.BMC infectious diseases · 2026Article
- Prevalence and risk factors of latent tuberculosis infection among household contacts of tuberculosis patients: a cross-sectional study.Frontiers in public health · 2026Article
- Association of tuberculosis infection with the development of active tuberculosis and comorbidities in rural China: a 10-year follow-up results of a population-based, multicentre, prospective study.The Lancet regional health. Western Pacific · 2025Article
- Sentinel-Site-Based Surveillance ofAntibiotics (Basel, Switzerland) · 2025Article
- Cross-District Transmission of Tuberculosis in a High-Mobility City in China: Implications for Regional Collaboration in Infectious Disease Control.Infection and drug resistance · 2025Article
- Transmission characteristics of tuberculosis in the high-TB-burden region of Southwest China.Frontiers in public health · 2025Article
- Genomic analysis of lineage-specific transmission of multidrug resistance tuberculosis in China.Emerging microbes & infections · 2024Article
- Transmission of tuberculosis in rural Henan, China: a prospective population-based genomic spatial epidemiological study.Emerging microbes & infections · 2024Article
- Drug-resistance characteristics, genetic diversity, and transmission dynamics of multidrug-resistant or rifampicin-resistant Mycobacterium tuberculosis from 2019 to 2021 in Sichuan, China.Antimicrobial resistance and infection control · 2024Article
- Drug-Resistant Profiles and Genetic Diversity ofInfection and drug resistance · 2024Article
- Surveillance of fluoroquinolones resistance in rifampicin-susceptible tuberculosis in eastern China with whole-genome sequencing-based approach.Frontiers in microbiology · 2024Article
- Discrepancy in the transmissibility of multidrug-resistantEmerging microbes & infections · 2023Article
- Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing.International journal of molecular sciences · 2023Article
- Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis.International journal of molecular sciences · 2023Review
- Whole Genomic Analysis Revealed High Genetic Diversity and Drug-Resistant Characteristics ofInfection and drug resistance · 2023Article
- Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China.Infection and drug resistance · 2023Article
- Assessing the spatial heterogeneity of tuberculosis in a population with internal migration in China: a retrospective population-based study.Frontiers in public health · 2023Article
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21 authors at 8 institutions in 3 countries.
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Abstract
backgroundUnderstanding the transmission of Mycobacterium tuberculosis is essential for the development of efficient tuberculosis control strategies. China has the second-largest tuberculosis burden in the world. Recent transmission and infection with M. tuberculosis, particularly drug-resistant strains, may account for many new tuberculosis cases.
methodsWe performed a population-based molecular epidemiologic study of pulmonary tuberculosis in China during 1 July 2009 to 30 June 2012. We defined clusters as cases with identical variable number tandem repeat genotype patterns and identified the risk factors associated with clustering, by logistic regression. Relative transmission rates were estimated by the sputum smear status and drug susceptibility status of tuberculosis patients.
resultsAmong 2274 culture-positive tuberculosis patients with genotyped isolates, there were 705 (31.0%) tuberculosis patients in 287 clusters. Multidrug-resistant (MDR) tuberculosis (adjusted odds ratio [aOR], 1.86; 95% confidence interval [CI], 1.25-2.63) and infection with a Beijing family strain (aOR, 1.56; 95% CI, 1.23-2.96) were associated with clustering. Eighty-four of 280 (30.0%) clusters had a putative source case that was sputum smear negative, and 30.6% of their secondary cases were attributed to transmission by sputum smear-negative patients. The relative transmission rate for sputum smear negative compared with sputum smear-positive patients was 0.89 (95% CI, .68-1.10), and was 1.51 (95% CI, 1.00-2.24) for MDR tuberculosis vs drug-susceptible tuberculosis.
conclusionsRecent transmission of M. tuberculosis, including MDR strains, contributes substantially to tuberculosis disease in China. Sputum smear-negative cases were responsible for at least 30% of the secondary cases. Interventions to reduce the transmission of M. tuberculosis should be implemented in China.
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