ArticleChromosoma1989
DNA loop domains in mammalian spermatozoa.
Article in Chromosoma, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- The Art of Packaging the Sperm Genome: Molecular and Structural Basis of the Histone-To-Protamine Exchange.Frontiers in endocrinology · 2022Review
- Functional Aspects of Sperm Chromatin Organization.Results and problems in cell differentiation · 2022Review
- Organization of sperm DNA by the nuclear matrix.American journal of clinical and experimental urology · 2018Review
- Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond.Cellular and molecular life sciences : CMLS · 2017Review
- Mammalian sperm nuclear organization: resiliencies and vulnerabilities.Basic and clinical andrology · 2016Article
- Double-stranded DNA breaks hidden in the neutral Comet assay suggest a role of the sperm nuclear matrix in DNA integrity maintenance.Molecular human reproduction · 2014Article
- Isolation of sperm nuclei and nuclear matrices from the mouse, and other rodents.Methods in molecular biology (Clifton, N.J.) · 2013Article
- "Breaking news" from spermatids.Basic and clinical andrology · 2013Article
- Mammalian sperm chromatin as a model for chromatin function in DNA degradation and DNA replication.Systems biology in reproductive medicine · 2011Review
- The sperm nucleus: chromatin, RNA, and the nuclear matrix.Reproduction (Cambridge, England) · 2011Review
- Non-genetic contributions of the sperm nucleus to embryonic development.Asian journal of andrology · 2011Review
- Function of sperm chromatin structural elements in fertilization and development.Molecular human reproduction · 2010Review
- Paternal contributions: new functional insights for spermatozoal RNA.Journal of cellular biochemistry · 2008Review
- Mouse spermatozoa contain a nuclease that is activated by pretreatment with EGTA and subsequent calcium incubation.Journal of cellular biochemistry · 2008Article
- Decondensing the protamine domain for transcription.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Roles of transition nuclear proteins in spermiogenesis.Chromosoma · 2003Review
- AFM analysis of DNA-protamine complexes bound to mica.Nucleic acids research · 1997Article
- Atomic force microscopy of mammalian sperm chromatin.Chromosoma · 1993Article
- Chromosome length and DNA loop size during early embryonic development of Xenopus laevis.Chromosoma · 1993Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The highly condensed and tightly packaged DNA of hamster spermatozoa was found to be organized into topologically constrained DNA loop domains attached at their bases to a nuclear matrix. The loop domains of the sperm nuclei differed from somatic cell loop domains from the same animal in two aspects. Sperm loop domains were 60% smaller than somatic cell loop domains, with an average DNA length of 46 +/- 7 kb in sperm as compared with 76 +/- 11 kb in brain. Secondly, unlike virtually all somatic cell DNA known which is negatively supercoiled, sperm DNA was devoid of detectable supercoiling. The presence of the loop domain structure in the highly condensed DNA of mammalian spermatozoa suggests that this motif is a fundamental aspect of eukaryotic DNA organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.