Evidence map›Paper›PMID 25828624›Full record

Trial reportEuropean journal of clinical nutrition2015

Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes.

U Masharani, P Sherchan, M Schloetter, S Stratford, A Xiao, A Sebastian, M Nolte Kennedy, L Frassetto

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 6 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
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  13. Article
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  17. Article
  18. Fad Diets: Facts and Fiction.Frontiers in nutrition · 2022
    Review
  19. Article
  20. Poor Medication Adherence in African Americans Is a Matter of Trust.Journal of racial and ethnic health disparities · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

U MasharaniDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
P SherchanDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
M SchloetterClinical and Translational Science Institute, University of California San Francisco, San Francisco, CA, USA.
S StratfordDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
A XiaoDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
A Sebastian1] Department of Medicine, University of California San Francisco, San Francisco, CA, USA [2] Clinical and Translational Science Institute, University of California San Francisco, San Francisco, CA, USA.
M Nolte KennedyDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
L FrassettoDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USSouthern California Clinical and Translational Science Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe contemporary American diet figures centrally in the pathogenesis of numerous chronic diseases--'diseases of civilization'--such as obesity and diabetes. We investigated in type 2 diabetes whether a diet similar to that consumed by our pre-agricultural hunter-gatherer ancestors ('Paleolithic' type diet) confers health benefits. SUBJECTS/

methodsWe performed an outpatient, metabolically controlled diet study in type 2 diabetes patients. We compared the findings in 14 participants consuming a Paleo diet comprising lean meat, fruits, vegetables and nuts, and excluding added salt, and non-Paleolithic-type foods comprising cereal grains, dairy or legumes, with 10 participants on a diet based on recommendations by the American Diabetes Association (ADA) containing moderate salt intake, low-fat dairy, whole grains and legumes. There were three ramp-up diets for 7 days, then 14 days of the test diet. Outcomes included the following: mean arterial blood pressure; 24-h urine electrolytes; hemoglobin A1c and fructosamine levels; insulin resistance by euglycemic hyperinsulinemic clamp and lipid levels.

resultsBoth groups had improvements in metabolic measures, but the Paleo diet group had greater benefits on glucose control and lipid profiles. Also, on the Paleo diet, the most insulin-resistant subjects had a significant improvement in insulin sensitivity (r = 0.40, P = 0.02), but no such effect was seen in the most insulin-resistant subjects on the ADA diet (r = 0.39, P = 0.3).

conclusionsEven short-term consumption of a Paleolithic-type diet improved glucose control and lipid profiles in people with type 2 diabetes compared with a conventional diet containing moderate salt intake, low-fat dairy, whole grains and legumes.

Indexed as

Diet, DiabeticDiet, PaleolithicDiet, WesternAgedBlood PressureDiabetes Mellitus, Type 2ElectrolytesFemaleFoodFructosamineGlucose Clamp TechniqueGlycated HemoglobinHumansInsulin ResistanceLipidsMaleElectrolytesFructosamineGlycated Hemoglobinhemoglobin A1c protein, humanLipids

Identifiers

PMID25828624
OpenAlexW2030527483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.