ArticleEvolution; international journal of organic evolution2015
Origin, evolution, and population genetics of the selfish Segregation Distorter gene duplication in European and African populations of Drosophila melanogaster.
Article in Evolution; international journal of organic evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Pervasive suppressors halt the spread of selfish Segregation Distorter in a natural population.Genetics · 2026Article
- Disruption of small RNAs and mechanistic variation in Segregation Distorter: A sperm-killing drive system in Drosophila melanogaster.PLoS genetics · 2026Article
- Pervasive suppressors halt the spread of selfishbioRxiv : the preprint server for biology · 2025Article
- Novel stressors and trait variation determine X-linked meiotic drive frequency.Proceedings. Biological sciences · 2025Article
- New perspectives on the causes and consequences of male meiotic drive.Current opinion in genetics & development · 2023Review
- Predicting recombination suppression outside chromosomal inversions in Drosophila melanogaster using crossover interference theory.Heredity · 2023Article
- Article
- Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Epistatic selection on a selfisheLife · 2022Article
- Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross line.Genetics · 2022Article
- Sexual selection can partly explain low frequencies ofProceedings. Biological sciences · 2021Article
- A common gene drive language eases regulatory process and eco-evolutionary extensions.BMC ecology and evolution · 2021Article
- Selfing is the safest sex foreLife · 2021Article
- Resistance to natural and synthetic gene drive systems.Journal of evolutionary biology · 2020Review
- Analysis of a Strong Suppressor of Segregation Distorter inGenetics · 2020Article
- Functional Significance of Satellite DNAs: Insights FromFrontiers in cell and developmental biology · 2020Review
- Ancient gene drives: an evolutionary paradox.Proceedings. Biological sciences · 2019Article
- An X-linked meiotic drive allele has strong, recessive fitness costs in femaleProceedings. Biological sciences · 2019Article
- Meiotic drive mechanisms: lessons fromProceedings. Biological sciences · 2019Article
- An assessment of the immune costs associated with meiotic drive elements inProceedings. Biological sciences · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Meiotic drive elements are a special class of evolutionarily "selfish genes" that subvert Mendelian segregation to gain preferential transmission at the expense of homologous loci. Many drive elements appear to be maintained in populations as stable polymorphisms, their equilibrium frequencies determined by the balance between drive (increasing frequency) and selection (decreasing frequency). Here we show that a classic, seemingly balanced, drive system is instead characterized by frequent evolutionary turnover giving rise to dynamic, rather than stable, equilibrium frequencies. The autosomal Segregation Distorter (SD) system of the fruit fly Drosophila melanogaster is a selfish coadapted meiotic drive gene complex in which the major driver corresponds to a partial duplication of the gene Ran-GTPase activating protein (RanGAP). SD chromosomes segregate at similar, low frequencies of 1-5% in natural populations worldwide, consistent with a balanced polymorphism. Surprisingly, our population genetic analyses reveal evidence for parallel, independent selective sweeps of different SD chromosomes in populations on different continents. These findings suggest that, rather than persisting at a single stable equilibrium, SD chromosomes turn over frequently within populations.
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