ArticleThe Journal of infectious diseases2015
18F-fluorodeoxyglucose Positron Emission Tomography in Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease: Correlation With Activity, Severity, Inflammatory and Virologic Parameters.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Exploring the link between IgE-mediated inflammation and cardiorenal function in adults living with and without HIV.Discover public health · 2026Article
- Advances in the Molecular Imaging of Sarcoma: An Emphasis on Metabolic Imaging.Molecular imaging and biology · 2025Review
- Article
- Unicentric Castleman disease with paraneoplastic pemphigus in a young woman: a case report.Frontiers in medicine · 2025Article
- HIV-associated cancers and lymphoproliferative disorders caused by Kaposi sarcoma herpesvirus and Epstein-Barr virus.Clinical microbiology reviews · 2024Review
- A variant of KSHV-associated inflammatory cytokine syndrome in elderly men of Mediterranean descent.Infection · 2024Article
- Deconstructing the liquid architecture of human herpesvirus 8 diseases.British journal of haematology · 2023Article
- PET-CT in Clinical Adult Oncology-VI. Primary Cutaneous Cancer, Sarcomas and Neuroendocrine Tumors.Cancers · 2022Review
- Yield of FDG PET/CT for Defining the Extent of Disease in Patients with Kaposi Sarcoma.Cancers · 2022Article
- Oncologic Treatment of HIV-Associated Kaposi Sarcoma 40 Years on.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Review
- Castleman disease.Nature reviews. Disease primers · 2021Review
- FDG PET/CT Findings of Castleman Disease Assessed by Histologic Subtypes and Compared with Laboratory Findings.Diagnostics (Basel, Switzerland) · 2020Article
- Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease.Internal medicine (Tokyo, Japan) · 2019Article
- Embolization of blood-supply artery followed by surgery for treatment of mesorectal Castleman's disease: case report and literature review.Gastroenterology report · 2019Article
- Human immunodeficiency virus-negative multicentric Castleman's disease coexistent with Kaposi's sarcoma onMolecular and clinical oncology · 2019Article
- Treatment of Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease.Hematology/oncology clinics of North America · 2018Review
- Article
- An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis.PLoS pathogens · 2016Article
- Clinical Features and Outcomes of Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV)-associated Inflammation: Prospective Characterization of KSHV Inflammatory Cytokine Syndrome (KICS).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Update and new approaches in the treatment of Castleman disease.Journal of blood medicine · 2016Review
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundKaposi sarcoma herpesvirus (KSHV)-associated multicentric Castleman disease (MCD) is a lymphoproliferative inflammatory disorder commonly associated with human immunodeficiency virus (HIV). Its presentation may be difficult to distinguish from HIV and its complications, including lymphoma. Novel imaging strategies could address these problems.
methodsWe prospectively characterized (18)F-fluorodeoxyglucose positron emission tomography (PET) findings in 27 patients with KSHV-MCD. Patients were imaged with disease activity and at remission with scans evaluated blind to clinical status. Symptoms, C-reactive protein level, and HIV and KSHV loads were assessed in relation to imaging findings.
resultsKSHV-MCD activity was associated with hypermetabolic symmetric lymphadenopathy (median maximal standardized uptake value [SUVmax], 6.0; range, 2.0-8.0) and splenomegaly (3.4; 1.2-11.0), with increased metabolism also noted in the marrow (2.1; range, 1.0-3.5) and salivary glands (3.0; range, 2.0-6.0). The (18)F-fluorodeoxyglucose PET abnormalities improved at remission, with significant SUVmax decreases in the lymph nodes (P = .004), spleen (P = .008), marrow (P = .004), and salivary glands (P = .004). Nodal SUVmax correlated with symptom severity (P = .005), C-reactive protein level (R = 0.62; P = .004), and KSHV load (R = 0.54; P = .02) but not HIV load (P = .52).
conclusionsKSHV-MCD activity is associated with (18)F-FDG PET abnormalities of the lymph nodes, spleen, marrow, and salivary glands. These findings have clinical implications for the diagnosis and monitoring of KSHV-MCD and shed light on its pathobiologic mechanism.
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