Evidence map›Paper›PMID 25827661›Full record

ArticleMedical molecular morphology2016

A resected case of neuroendocrine carcinoma of the stomach with unusual lymph node metastasis.

Jun Taguchi, Koji Shinozaki, Shinji Baba, Junichi Kurogi, Tomoyuki Nakane, Yoshihiro Kinoshita, Kunihide Ishii, Takato Ueno, Takuji Torimura, Hirohisa Yano

Abstract readCase Reports
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In one paragraph

Article in Medical molecular morphology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Gastric Neuroendocrine Carcinoma with Rapid Progression.Internal medicine (Tokyo, Japan) · 2020
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jun TaguchiDivision of Pathology, Asakura Medical Association Hospital, 422-1 Raiha, Asakura, Fukuoka, 830-0069, Japan. taguchi.jn@asakura-med.or.jp.
Koji ShinozakiDivision of Surgery, Asakura Medical Association Hospital, Asakura, Fukuoka, Japan.
Shinji BabaDivision of Gastroenterology, Department of Internal Medicine, Asakura Medical Association Hospital, Asakura, Fukuoka, Japan.
Junichi KurogiDivision of Gastroenterology, Department of Internal Medicine, Asakura Medical Association Hospital, Asakura, Fukuoka, Japan.
Tomoyuki NakaneDivision of Gastroenterology, Department of Internal Medicine, Asakura Medical Association Hospital, Asakura, Fukuoka, Japan.
Yoshihiro KinoshitaDivision of Gastroenterology, Department of Internal Medicine, Asakura Medical Association Hospital, Asakura, Fukuoka, Japan.
Kunihide IshiiDivision of Gastroenterology, Department of Internal Medicine, Asakura Medical Association Hospital, Asakura, Fukuoka, Japan.
Takato UenoDivision of Gastroenterology, Department of Internal Medicine, Asakura Medical Association Hospital, Asakura, Fukuoka, Japan.
Takuji TorimuraDivision of Gastroenterology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Hirohisa YanoDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Japan Hospital Association · JPKurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric endocrine cell carcinoma is a relatively rare tumor. We experienced a case of early gastric cancer in which an endocrine cell carcinoma was identified within a differentiated adenocarcinoma, and a component of this endocrine cell carcinoma had metastasized to lymph nodes of the stomach. In its 2010 revision regarding digestive system tumors, WHO classified cancer cells with characteristics of both glandular system cells and neuroendocrine cells as mixed adeno neuroendocrine carcinoma (MANEC) under the neuroendocrine carcinoma (NEC) category. In this case, we observed an endocrine cell carcinoma continuous with an intramucosal differentiated adenocarcinoma, and cancer cells with an irregular gland duct structure were observed in the proliferative portion of the submucosal tissue. In addition, there was a 35 mm size lymph node metastasis in the lesser curvature of the stomach consisting entirely of poorly differentiated cancer cells with polymorphic, highly atypical nuclei and scant cytoplasm. Immunohistological analysis showed that the endocrine carcinoma in the gastric mucosa was chromogranin A positive and the infiltrated area of the submucosal tissue was also chromogranin A positive. The lymph node metastasis was positive not only for chromogranin A, but also for Synaptophysin and CD56. Furthermore, the Ki67 labeling index was high at approximately 80 % for the gastric endocrine cell carcinoma and approximately 90 % for the lymph node metastases. Until now, there are no reports related to the patients with early gastric cancer accompanied with lymph node metastasis of MANEC. This case is very interested in considering the mechanism of lymph node metastasis of MANEC. The patient has shown no sign of recurrence for 1 year and 4 months after postoperative chemotherapy.

Indexed as

Carcinoma, NeuroendocrineChromogranin AHumansLymphatic MetastasisMaleMiddle AgedStomach NeoplasmsTomography, X-Ray ComputedChromogranin AAdenocarcinomaGastric cancerImmunohistochemistryNeuroendocrine carcinoma

Identifiers

PMID25827661
OpenAlexW2006139816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.