ArticleThe Laryngoscope2015
Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis.
Article in The Laryngoscope, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Antiviral defenses are diminished at birth in cystic fibrosis pig airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026Article
- Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Cystic fibrosis transmembrane conductance regulator in COPD: a role in respiratory epithelium and beyond.The European respiratory journal · 2023Review
- Extracorporeal high-frequency combined with contrast-enhanced ultrasound: a novel imaging method for detection and treatment evaluation of patients with cervical trachea-associated relapsing polychondritis.Annals of translational medicine · 2021Article
- Tracheal cartilaginous sleeve diagnosed on ultrasound in a child with Pfeiffer syndrome.International journal of pediatric otorhinolaryngology · 2020Article
- Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques.The Journal of clinical investigation · 2018Article
- Ultrasound diagnosis of tracheal cartilaginous sleeve in a patient with Pfeiffer syndrome.Pediatric radiology · 2018Article
- The dosage-dependent effect exerted by the NM23-H1/H2 homolog NDK-1 on distal tip cell migration in C. elegans.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Postnatal airway growth in cystic fibrosis piglets.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Inflammatory Diseases and Growth: Effects on the GH-IGF Axis and on Growth Plate.International journal of molecular sciences · 2017Review
- Biomimetic heterogenous elastic tissue development.NPJ Regenerative medicine · 2017Article
- Lessons learned from the cystic fibrosis pig.Theriogenology · 2016Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectives/hypothesisTracheal cartilage ring structural abnormalities have been reported in cystic fibrosis (CF) mice and pigs. Whether similar findings are present in humans with CF is unknown. We hypothesized that tracheal cartilage ring shape and size would be different in people with CF. STUDY
designTracheal cartilage ring size and shape were measured in adults with (n = 21) and without CF (n = 18).
methodsUltrasonography was used in human subjects to noninvasively assess tracheal cartilage ring structure in both the sagittal and the transverse planes. Tracheal cartilage ring thickness was also determined from histological sections obtained from newborn non-CF and CF pigs. These values were compared with human data.
resultsHuman CF tracheas had a greater width and were less circular in shape compared to non-CF subjects. CF tracheal cartilage rings had a greater midline cross-sectional area and were thicker compared to non-CF rings. Maximal tracheal cartilage ring thickness was also greater in both newborn CF pigs and human adults with CF, compared to non-CF controls.
conclusionsOur findings demonstrate that structural differences exist in tracheal cartilage rings in adults with CF. Comparison with newborn CF pig data suggests that some of these changes may be congenital in nature. LEVEL OF EVIDENCE: 3b
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