ArticleThe American journal of emergency medicine2015
Clinical diagnosis of influenza in the ED.
Article in The American journal of emergency medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05467007 (Urgent Care Management of Respiratory Illness Enabled With Novel Testing Pathway), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urgent Care Management of Respiratory Illness Enabled With Novel Testing Pathway (URGENT): A Randomized Control Trial of Respiratory PCR Versus Standard Care
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis.Influenza and other respiratory viruses · 2016Pooled it
- Clinical impact of a routine, molecular, point-of-care, test-and-treat strategy for influenza in adults admitted to hospital (FluPOC): a multicentre, open-label, randomised controlled trial.The Lancet. Respiratory medicine · 2021Trial
- Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial.The Lancet. Respiratory medicine · 2017Trial
- The utility of syndromic respiratory pathogen panels: the premise of flexible and customizable approaches.Journal of clinical microbiology · 2025Article
- Point of Care Nucleic Acid Testing for Influenza-Like Illness: A Cost-Consequence Analysis for High-Risk Patients in Primary Care in Germany.Advances in therapy · 2025Article
- AI-assisted diagnostic approach for the influenza-like illness in children: decision support system for patients and clinicians.Biomedical engineering letters · 2025Article
- A multicenter randomized control trial: Point-of-care syndromic assessment versus standard testing in urgent care center patients with acute respiratory illness.Journal of the American College of Emergency Physicians open · 2024Article
- Do all Emergency Room Patients With Influenza-like Symptoms Need Blood Cultures? A Retrospective Cohort Study of 2 Annual Influenza Seasons.Open forum infectious diseases · 2024Article
- Single-Center Experience in Detecting Influenza Virus, RSV and SARS-CoV-2 at the Emergency Department.Viruses · 2023Article
- Cost-of-illness comparison between clinical judgment and molecular point-of-care testing for influenza-like illness patients in Germany.NPJ primary care respiratory medicine · 2023Article
- Point-of-Care Influenza Testing Impacts Clinical Decision, Patient Flow, and Length of Stay in Hospitalized Adults.The Journal of infectious diseases · 2022Observational
- Clinical diagnosis of seasonal influenza by physicians: a retrospective observational study.BMJ open · 2022Observational
- Review
- [Prevalence of microbiologically-confirmed influenza in patients with influenza-like illness in primary care and clinical and epidemiological characteristics].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Article
- Using an Individual-Centered Approach to Gain Insights From Wearable Data in the Quantified Flu Platform: Netnography Study.Journal of medical Internet research · 2021Article
- Viral community acquired pneumonia at the emergency department: Report from the pre COVID-19 age.Journal of medical virology · 2021Observational
- A remote household-based approach to influenza self-testing and antiviral treatment.Influenza and other respiratory viruses · 2021Article
- Suggestion of a simpler and faster influenza-like illness surveillance system using 2014-2018 claims data in Korea.Scientific reports · 2021Article
- Pre-clinically evaluated visual lateral flow platform using influenza A and B nucleoprotein as a model and its potential applications.RSC advances · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundTimely and accurate diagnosis of influenza remains a challenge but is critical for patients who may benefit from antiviral therapy. This study determined the test characteristics of provider diagnosis of influenza, final ED electronic medical record (EMR) diagnosis of influenza, and influenza-like illness (ILI) in patients recommended to receive antiviral treatment according to Centers for Disease Control and Prevention (CDC) guidelines. In addition, we evaluated the compliance with CDC antiviral guidelines.
methodsA prospective cohort of adults presenting to a tertiary care ED with an acute respiratory illness who met CDC criteria for recommended antiviral treatment were enrolled and tested for influenza. A clinical diagnosis of influenza was assessed by asking the clinician: "Do you think this patient has influenza?" Influenza-like illness was defined according to current CDC criteria.
resultsIn this cohort of 270 subjects, 42 (16%; 95% confidence interval [CI], 11%-20%) had influenza. Clinician diagnosis had a sensitivity of 36% (95% CI, 22%-52%) and specificity of 78% (95% CI, 72%-83%); EMR final ED diagnosis had a sensitivity of 26% (95% CI, 14%-42%) and specificity of 97% (95% CI, 94%-99%); ILI had a sensitivity of 31% (95% CI, 18%-47%) and specificity of 88% (95% CI, 83%-92%). Only 15 influenza-positive patients (36%) received antiviral treatment.
conclusionClinician diagnosis, final ED EMR diagnosis, and ILI have low sensitivity for diagnosing influenza, and there is overall poor compliance with CDC antiviral treatment recommendations. Improved methods of influenza diagnosis are needed to help guide management in the clinical setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.